Speaker:
Xiongwen Chen
Professor
Dean of School of Pharmacy, Tianjin Medical University
Topic:
The role of Calcium Signal and Sympathetic Adrenergic Signal in Heart Disease and Drug Development Ideas
Date:
May 26th, 2021, 2:30 P.M.
Venue:
College of Pharmacy, Lecture Hall 114
Abstract：
Cardiac function is regulated constantly to meet the perfusion demand of body under physiological and pathological conditions. Calcium plays a critical role in cardiac contraction. It also regulates many biological processes in the heart, such as heart cell growth, metabolism, gene transcription and cell death. Abnormal Ca2+ signaling in the heart leads to cardiac hypertrophy, arrhythmias, and heart failure. In the heart, calcium signal is regulated by the b-adrenergic signaling to enhance cardiac contractility. Persistently activated b-adrenergic system is a major drive for the development of heart disease. While both calcium and b-adrenergic signaling have been extensively studied, many novel aspects of these signaling systems have been reported recently with some contribution from our group. This seminar will present our findings regarding the roles of the calcium channels and b-adrenergic signaling in heart physiology and pathology. Also, novel potential targets for heart disease treatment are to be discussed.
