Nankai team revealed the catalytic mechanism of the main protease of MERS-CoV and SARS-CoV


Recently, through continuous researches, Professor Shang Lu Qing, from College of Pharmacy, reveals the catalytic mechanism of coronavirus main proteinase, discussed the coronavirus MERS - CoV with SARS - CoV main protease in the process of catalytic difference, and then optimizes the biological activity of the main protease inhibitors. This work lays the foundation for future research in response to the mutation of the coronavirus and is intended to assist in the development of anti-novel coronavirus drugs. A paper describing the results was published in ACS Catalysis.

Professor Shang Luqing, Associate professor Li Dongmei are the co-corresponding authors. The research was supported by the National Key Research and Development Program, the National Natural Science Foundation of China and the Natural Science Foundation of Tianjin.

The thesis links: