Wei Zhao
Professor
· Work Address: College of Pharmacy, Nankai University
· Telephone: +86-22-23507760
· E-mail: wzhao@nankai.edu.cn
Research Areas
Glycobiology, Medicinal Chemistry, Chemical Biology
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
12. Wenjun Wang, Zhongyue Yang, Yun Xu, Taibao Liu, Tianbang Song, Yunyan Zhao, Xiufang Xu*, Wei Zhao* and Peng George Wang*, ““Armed and disarmed” theory in the addition of an azide radical to glucals”, RSC Advances, 2015, 5 , 38577 - 38580.
11. Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin, Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao* and Peng George Wang *.. “Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors”. Bioorganic & Medicinal Chemistry. 19 (2011) 2136–2144.
10. Lina Guo, Taibao Liu, Kai Chen, Tianbang Song, Peng George Wang* and Wei Zhao*, “Facile synthesis of 5-hydroxy-L-lysine from D-galactose as a chiral-precursor”, Organic & Biomolecular Chemistry, 2014, 12, 7310–7317.
9. Tiehai Li, Hui Ye, Xuefeng Cao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen*, Wei Zhao*, and Peng Wang*, “Total Synthesis of Anticoagulant Pentasaccharide Fondaparinux”. ChemMedChem 2014, 9, 1071 – 1080.
8. Yi, Wen; Liu, Xianwei; Xia, Chengfeng; Zhao, Wei; Zhang, Wenpeng; Chen, Xi; Wang, Peng G. “Remodeling Bacterial Polysaccharides by Metabolic Pathway Engineering” Proceedings of the National Academy of Sciences, 2009, 106(11), 4207-4212.
7. Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao*, and Peng George Wang*,“Efficient Enzymatic Synthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters. 2013, 21, 5528–5530.
6. Cai, Li; Guan, Wanyi; Wang, Wenjun; Zhao, Wei; Kitaoka, Motomitsu; Shen, Jie; O'Neil, Crystal; Wang, Peng George. “Substrate specificity of N-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.” Bioorganic & Medicinal Chemistry Letters 2009, 19, 5433-5435.
5. Lina Guo, Yonghui Liu, Yue Wan, Peng George Wang and Wei Zhao*,“Effective and one-step stereo-controlled synthesis of polybenzyloxylateddiiodopentanes for the synthesis of five-membered imino-sugars”. Tetrahedron Letters. 2013, 54，2579-2582.
4. Tiehai Li, Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang*, Wei Zhao*, “Elevation of cellular O-GlcNAcylation level by a potent and selective O-GlcNAcase inhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic & Medicinal Chemistry Letters. 22 (2012) 6854-6857.
3. Lei Li, Yonghui Liu, Wenjun Wang, Jiansong Cheng, Wei Zhao*, and Peng Wang*. “A Highly Efficient Galactokinase from Bifidobacterium infantis with Broad Substrate Specificity.” Carbohydrate Research, 2012, 355C, 34-38.
2. Lina Guo, Yue Wan, Xin Wang, Peng George Wang, Wei Zhao*,“Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry.”Mini-Reviews in Medicinal Chemistry. 2012, 12, 1533-1541.
1. Wenjun Wang, Chen Jin, Lina Guo, Yu Liu, Yue Wan, Xin Wang, Lei Li, Wei Zhao*, Peng George Wang*,“Preparation of oligosaccharides by homogenous enzymatic synthesis and solid phase extraction.” Chemical Communications, 2011, 47, 11240-11242.
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Teaching
[1]Undergraduate: Medicinal Chemistry
[2]Master: Chemical Biology
