Quan Zhang
Professor
· Work Address: College of Pharmacy, Nankai University
· Telephone: +86-22-85358387
· E-mail: zhangquan@nankai.edu.cn
Research Areas
Medicinal Chemistry, Total Synthesis, Chemical Biology, Target of Natural Products
Awards
[1]2017.08, Chinese Pharmaceutical Association- Servier Young Investigator Awards in Medicinal Chemistry, Chinese Pharmaceutical Association
[2]2015.03, Young Scientific and Technological Talents of Tianjin Innovation Talent Promotion Program, Tianjin City
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
1. Yahui Ding, Xiaoping Chen, Can Liu, Weizhi Ge, Qin Wang, Xin Hao, Mengmeng Wang, Yue Chen*, Quan Zhang*, Identifcation of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells, J. Hematol. Oncol. 2021, 14, 19.
2. Fangzhi Han, Guangju Liu, Xuhai Zhang, Yahui Ding, Liang Wang, Yijing Wu, Yue Chen,* and Quan Zhang*, Total Synthesis and Structure Revision of Boholamide A, Org. Lett. 2021, 23, 4976−4980.
3. Yahui Ding, Qingqing Xue, Shuo Liu, Kai Hu, Da Wang, Tianpeng Wang, Ye Li, Hongyu Guo, Xin Hao, Weizhi Ge, Yan Zhang, Ang Li, Jing Li*, Yue Chen*, Quan Zhang*, Identification of parthenolide dimers as activators of pyruvate kinase M2 in xenografts of glioblastoma multiforme in vivo, J. Med. Chem. 2020, 63, 1597−1611. (Selected as Supplementary Cover)
4. Yahui Ding#, Tianpeng Wang#, Tianyang Chen, Chunfeng Xie*, Quan Zhang*, Sesquiterpenoids isolated from the flower of Inula japonica as potential antitumor leads for intervention of paclitaxel-resistant non-small-cell lung cancer, Bioorg. Chem. 2020, 101, 103973. (#Contributed equally)
5. Yahui Ding#, Shengzu Li#, Weizhi Ge, Zhongquan Liu, Xuhai Zhang, Mengmeng Wang, Tianyang Chen, Yue Chen*, Quan Zhang*, Design and synthesis of parthenolide and 5-fluorouracil conjugates as potential anticancer agents against drug resistant hepatocellular carcinoma, Eur. J. Med. Chem. 2019, 183, 111706. (#Contributed equally)
6. Weizhi Ge, Xin Hao, Fangzhi Han, Zhongquan Liu, Tianpeng Wang, Mengmeng Wang, Ning Chen, Yahui Ding*, Yue Chen*, Quan Zhang*, Synthesis and structure-activity relationship studies of parthenolide derivatives as potential anti-triple negative breast cancer agents, Eur. J. Med. Chem. 2019, 166, 445−469.
7. Yahui Ding#, Wenwei Pan#, Junqing Xu#, Tianpeng Wang, Tianyang Chen, Zhongquan Liu, Chunfeng Xie*, Quan Zhang*, Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells, Bioorg. Chem. 2019, 86, 363−367. (#Contributed equally)
8. Weizhi Ge, Zhongquan Liu, Yu Sun, Tianpeng Wang, Hongyu Guo, Xinyi Chen, Shengzu Li, Mengmeng Wang, Yue Chen*, Yahui Ding*, Quan Zhang*, Design and synthesis of parthenolide-SAHA hybrids for intervention of drugresistant acute myeloid leukemia, Bioorg. Chem. 2019, 87, 699–713.
9. Yahui Ding#, Hongyu Guo#, Weizhi Ge#, Xinyi Chen, Shengzu Li, Mengmeng Wang, Yue Chen, Quan Zhang*, Copper(I) oxide nanoparticles catalyzed click chemistry based synthesis of melampomagnolide B-triazole conjugates and their anti-cancer activities, Eur. J. Med. Chem. 2018, 156, 216−229. (#Contributed equally)
10. Jian Chen, Jingpei Li, Lingling Wu, Yan Geng, Jianming Yu, Chuanke Chong, Mengmeng Wang, Yuan Gao, Cuigai Bai, Yahui Ding*, Yue Chen*, Quan Zhang*, Syntheses and anti-pancreatic cancer activities of rakicidin analogues, Eur. J. Med. Chem. 2018, 128, 601−627.
11. Zhongjin Yang#, Beijia Kuang#, Ning Kang, Yahui Ding, Weizhi Ge, Lihui Lian, Yuan Gao, Yuqing Wei, Yue Chen*, Quan Zhang*, Synthesis and anti-acute myeloid leukemia activity of C-14 modified parthenolide derivatives, Eur. J. Med. Chem. 2017, 127, 296–304. (#Contributed equally)
12. Feng Sang#, Yahui Ding#, Jinghan Wang#, Bingxia Sun#, Jianlei Sun#, Yan Geng#, Zhang Zhang, Ke Ding, Ling-Ling Wu, Jian-Wei Liu, Cuigai Bai, Guang Yang*, Quan Zhang*, Lu-Yuan Li*, Yue Chen*, Structure−activity relationship study of rakicidins: Overcoming chronic myeloid leukemia resistance to imatinib with 4‑methylester-rakicidin A, J. Med. Chem. 2016, 59, 1184−1196.(#Contributed equally)
13. Yahui Ding, Huier Gao, Yu Zhang, Ye Li, Neil Vasdev, Yingdai Gao†, Yue Chen† and Quan Zhang*,†, Alantolactone selectively ablates acute myeloid leukemia stem and progenitor cells, J. Hematol. Oncol. 2016, 9:93. (†Contributed equally)
14. Zhong-Jin Yang, Wei-Zhi Ge, Qiu-Ying Li, Yaxin Lu, Jian-Miao Gong, Bei-Jia Kuang, Xiaonan Xi, Haiting Wu, Quan Zhang*, and Yue Chen*, Syntheses and biological evaluation of costunolide, parthenolide, and their fluorinated analogues, J. Med. Chem. 2015, 558, 7007−7020.
15. Jing Long, Shan-Feng Zhang, Pan-Pan Wang, Xue-Mei Zhang, Zhong-Jin Yang, Quan Zhang* and Yue Chen*, Total syntheses of parthenolide and its analogs with macrocyclic stereocontrol, J. Med. Chem. 2014, 57, 7098–7112.
16. Quan Zhang,# Yaxin Lu,# Yahui Ding,# Jiadai Zhai,# Qing Ji,# Weiwei Ma, Ming Yang, Hongxia Fan, Jing Long, Bin Han, Wenpeng Zhang, Chuanjiang Qiu, Xiaoyan Ma, Zhongsheng Tong, Yehui Shi, Yongsheng Jia, Qianqian Shi, Haoliang Zhang, Dongmei Li, Jing Zhang, Jianping Lin, Lu-Yuan Li, Yingdai Gao, Yue Chen, Guaianolide Sesquiterpene Lactones, a Source to Discover Agents That Selectively Ablate Acute Myelogenous Leukemia Stem and Progenitor Cells, J. Med. Chem. 2012, 55, 8757−8769. (#Contributed equally)
Teaching
[1]Undergraduate: Development of New Drugs and Intellectual Property Rights; Medicinal Chemistry; Experimental teaching of Medicinal Chemistry
[2]Master: Application and Management of Research Project
