Bo Su, Ph.D.
Professor
Distinguished Young Scholars of Tianjin
Hundred Young Academic Leader of Nankai University
Group website: https://sulab.nankai.edu.cn/
Orcid ID: 0000-0002-1184-0828
Research & Education Background
2020-present Nankai University, Professor, State Key Laboratory of Medicinal Chemical Biology
2020-present Nankai University, Professor, College of Pharmacy
2016-2020 University of California, Berkeley Postdoc with Prof. John F. Hartwig
2017-2020 CARA (California Research Alliance) supported by BASF Project Scientist
BASF internal principal investigator: Dr. Martin Ernst
2013-2015 Peking university Postdoc with Prof. Zhang-Jie Shi
2013-2015 Peking university & MSD joint postdoc, Advisor in MSD: Dr. Wen-Lian Wu
2008-2013 Nankai university, Ph.D, Advisor: Prof. QingMin Wang
2004-2008 Zhengzhou university, B.S.
Research Interest:
1) to develop new chemical reactions that are catalyzed by transition metal complexes, particularly focusing on those with challenging selectivities—enantio-, diastereo-, chemo- and/or regioselectivity;
2) to address synthetic challenges associated with traditional organic transformations by transition metal catalysis;
3) to develop new carbon-main elements bond-forming reactions, including C-P, C-S, C-B, C-Si, etc.;
4) to expand the chemical space of medical chemistry by the application of state-of-the-art reactions.
Selected Publications (peer-reviewed):
25. Kang, J., Ding, K., Ren, S. M., Su, B.* Copper-Catalyzed Dynamic Kinetic Asymmetric P-C Coupling of Secondary Phosphine Oxides and Aryl iodides. Angew. Chem. Int. Ed. 2023, 62, e202301628.
24. Zhao, H., Lin, Y., Jiang, M., Su, B.* A General Catalytic Synthetic Strategy for Highly Strained Methylenecyclobutanes and Spiromethylenecyclobutanes, Chem. Sci., 2023, 14, 7879-7904.
23. Su B*, Hartwig J*, Development of Chiral Ligands for the Transition Metal‐catalyzed Enantioselective Silylation and Borylation of C‐H Bonds Angew. Chem. Int. Ed. 2022, 61, 9, e202113343
22. Liu J, Su B*, Chen M*，Cu-Catalyzed Highly Stereoselective Syntheses of (E)-δ-Vinyl-homoallylic Alcohols Org. Lett. 2021, 23, 6035-6040
21. Oeschger R,1 Su B,1 Yu I, Ehinger C, Romero E, He S, Hartwig J, Science 2020, 368, 736-741 (1Equal contribution)
20. B Su, A Bunescu, Y Qiu, SJ Zuend, M Ernst, JF Hartwig. J. Am. Chem. Soc. 2020, 142, 7912-7919.
19. Y Xi,1 B Su,1 X Qi, S Pedram, P Liu, JF Hartwig J. Am. Chem. Soc. 2020, 142, 18213-18222 (1Equal contribution)
18. Su, B.;1 Lee T.;1 Hartwig, J. F., Ir-Catalyzed Intramolecular Silylation of C-H Bonds of Aliphatic Amines. J. Am. Chem. Soc. 2018, 140, 18032. (1Equal contribution)
17. Su, B.; Hartwig, J. F., Ir-Catalyzed, Silyl-Directed, peri-Borylation of C-H Bonds in Fused Polycyclic Arenes and Heteroarenes Angew. Chem. Int. Ed. 2018, 57, 10163-10167.
16. Su, B.; Hartwig, J. F., Ir-Catalyzed Enantioselective, Intramolecular Silylation of Methyl C–H Bonds. J. Am. Chem. Soc. 2017, 139, 12137-12140.
15. Su, B.; Zhou, T.-G.; Xu, P.-L.; Shi, Z.-J.; Hartwig, J. F., Enantioselective Borylation of Aromatic C−H Bonds with Chiral Dinitrogen Ligands. Angew. Chem. Int. Ed. 2017, 56, 7205-7208.
14. Su, B.; Zhou, T.G.; Li, X.W.; Shao, X.R.; Xu, P.L.; Wu, W.L.; Hartwig, J. F.; Shi Z.-J., A Chiral Nitrogen Ligand for Enantioselective, Iridium-Catalyzed Silylation of Aromatic C-H Bonds. Angew. Chem. Int. Ed. 2017, 56, 1092-1096.
13. Su, B.; Cai, C.; Deng, M.; Wang, Q.-M., Spatial Configuration and Three-Dimensional Conformation Directed Design, Synthesis, Antiviral Activity, and Structure–Activity Relationships of Phenanthroindolizidine Analogues. J. Agric. Food. Chem. 2016, 64, 2039-2045.
12. Su, B.; Cao, Z.-C.; Shi, Z.-J., Exploration of Earth-Abundant Transition Metals (Fe, Co, and Ni) as Catalysts in Unreactive Chemical Bond Activations. Acc. Chem. Res. 2015, 48, 886-896.
11. Su, B.; Wei, J.B.; Wu, W.L.; Shi, Z.-J., Diversity-Oriented Synthesis through Rh-Catalyzed Selective Transformations of a Novel Multirole Directing Group. ChemCatChem 2015, 7, 2986-2990.
10. Su, B.; Zhang, H.; Deng, M.; Wang, Q.-M., An enantioselective strategy for the total synthesis of (S)-tylophorine via catalytic asymmetric allylation and a one-pot DMAP-promoted isocyanate formation/Lewis acid catalyzed cyclization sequence. Org. Biomol. Chem. 2014, 12, 3616-3621.
9. Su, B.;1 Deng, M.;1 Wang, Q.-M., Sodium Nitrite-Catalyzed Aerobic Oxidative Csp2-Csp3 Coupling: Direct Construction of the 4-Aryldihydroisoquinolinone Moiety. Adv. Synth. & Catal. 2014, 356, 977-981. (1Equal contribution)
8. Su, B.;1 Cai, C. L.;1 Deng, M.; Liang, D. M.; Wang, L. Z.; Wang, Q.-M, Design, synthesis, antiviral activity, and SARs of 13a-substituted phenanthroindolizidine alkaloid derivatives. Bioorg. Med. Chem. Lett. 2014, 24, 2881-2884. (1Equal contribution)
7. Su, B.;1 Chen, F.;1 Wang, L.; Wang, Q.-M., Design, Synthesis, Antiviral Activity, and Structure–Activity Relationships (SARs) of Two Types of Structurally Novel Phenanthroindo/ quinolizidine Analogues. J. Agric. Food. Chem. 2014, 62, 1233-1239. (1Equal contribution)
6. Yang, M. Y.; Su, B.; Wang, Y.; Chen, K.; Jiang, X. Y.; Zhang, Y. F.; Zhang, X. S.; Chen, G. H.; Cheng, Y.; Cao, Z. C.; Guo, Q. Y.; Wang, L. S.; Shi, Z. -J., Silver-catalysed direct amination of unactivated C-H bonds of functionalized molecules. Nature Commun. 2014, 5. 4707-4712.
5. Su, B.;1 Deng, M.;1 Wang, Q.-M.,Bioinspired Construction of a Spirocyclohexadienone Moiety via Sodium Nitrite Catalyzed Aerobic Intramolecular Oxidative Phenol Coupling. Org. Lett. 2013, 15, 1606–1609. (1Equal contribution)
4. Su, B.;1 Chen, F. Z.;1 Wang, Q.-M., A Novel Strategy for the Synthesis of Phenanthroindolizidine alkaloids via one-pot Intramolecular Schmidt/ Bischler-Napieralski/ Imine-reduction reaction. J. Org. Chem. 2013, 78, 2775–2779. (1Equal contribution)
3. Su, B.; Deng, M.; Wang, Q.-M., The first enantioselective approach to 13a-methyl-14-hydroxyphen- anthroindolizidine alkaloids: synthetic studies towards hypoestestatin 2. Eur. J. Org. Chem. 2013, 10, 1979–1985.
2. Su, B.; Cai, C. L.; Wang, Q.-M., Enantioselective Approach to 13a Methylphenanthroindolizidine Alkaloids. J. Org. Chem. 2012, 77, 7981–7987.
1. Su, B.; Li, L.; Hu, Y. N.; Liu, Y. X.; Wang, Q.-M., A Novel Sodium Nitrite-Catalyzed Oxidative Coupling for Constructing Polymethoxyphenanthrene Rings. Adv. Synth. Catal. 2012, 354, 383–387.
Social Service:
Early Career Advisory Board Member (2022-present)
Guest Editor for Molecules (2021)
Editorial Board as Topic Editors for Molecules (2020-present)
Awards:
l Thieme Chemistry Journals Awards (2024)
l Distinguished Young Scholars of Tianjin (2023)
l Hundred Young Academic Leaders Program of Nankai University (2019)
l China Postdoctoral Science Foundation (2014)
l Excellent Doctoral Dissertation of Nankai University (2014)
l MSD (Merck, U.S.) Postdoc Scholar Fellowship (2013)
l Doctoral National Scholarship (China) (2012)
l Nankai-PPG (PPG Industries, Inc) Scholarship (2012)
l Nankai University Outstanding Student Award (2012)
l Wan Xiang Scholarship (2011)
l Tai Da Kai-Lai Ying Scholarship (2009)
l Nankai University Scholarship for Outstanding Student (2009)
l Outstanding Graduates Award of ZhengZhou University (2008)
