Luqing Shang
Professor
· Work Address: College of Pharmacy, Nankai University
· Telephone: +86-22-23506290
· E-mail: shanglq@nankai.edu.cn
Research Areas
Antiviral drug, Medicinal Chemistry, Biological Chemistry
Awards
[1] 2016, Young Scientific and Technological Talents of Tianjin Innovation Talent Promotion Program
[2] 2015, The Third Level Candidates of Tianjin "131" Innovative Talents Training Project
5. Social Service
[1]]2012-Present, Member, Chinese Chemical Society
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
[1] Li N, Wang Z, Wang R, Zhang Z, Zhang Y, Deng C, Zhang B, Shang L, Ye H. (2021) In Vitro Inhibition of Alphaviruses by Lycorine. Virologica Sinica 8: 1-10.
[2] Zhuo L, Wang M, Yang J, Xu H, Huang W, Shang L, Yang G. (2021) Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology. Topics in Current Chemistry 379: 23.
[3] Liang X, Zhang L, Shi B, Chang H, Qiao D, Shen T, Zhao W, Yin Z, Shang L. (2020) Design and application of near-infrared fluorophore based on a novel thiazolidinedione-functionalized dicyanoisophorone. Talanta 220: 121433.
[4] Qiao D, Li L, Shen T, Yang J, Chang H, Liang X, Zhang L, Wang Q, Liu N, Zhao W, Shang L. (2020) Establishment of a Customizable Fluorescent Probe Platform for the Organelle-Targeted Bioactive Species Detection. ACS sensors 5: 2247–2254.
[5] Wang H, He S, Deng W, Zhang Y, Li G, Sun J, Zhao W, Guo Y, Yin Z, Li D, Shang L. (2020) Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease. ACS catalysis 10: 5871–5890.
[6] Ma Y, Li L, He S, Shang C, Sun Y, Liu N, Meek T D, Wang Y, Shang L. (2019) Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease. Journal of medicinal chemistry 62: 6146–6162.
[7] Liang X, Zhang L, Xu X, Qiao D, Shen T, Yin Z, Shang L. (2019) An ICT-based mitochondria-targeted fluorescent probe for hydrogen peroxide with a large turn-on fluorescence signal. Chemistry Select 4: 1330-1336.
[8] Ma Y, Shang C, Yang P, Li L, Zhai Y, Yin Z, Wang B, Shang L. (2018) 4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease. Journal of medicinal chemistry 61: 10333–10339.
[9] Qiao D, Shen T, Zhu M, Liang X, Zhang L, Yin Z, Wang B, Shang, L. (2018) A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H2S and various thiol species in solution and in live cells. Chemical communications (Cambridge, England) 54: 13252–13255.
[10] Nie Q, Xu X, Zhang Q, Ma Y, Yin Z, Shang L. (2018) 3D-quantitative structure-activity relationship study for the design of novel enterovirus A71 3C protease inhibitors. Chemical biology & drug design 92: 1750–1762.
[11] Fu S, Nie Q, Ma Y, Song P, Ren X, Luo C, Shang L, Yin Z. (2018) Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease. Chemical communications (Cambridge, England) 54: 2890–2893.
[12] Liang X, Xu X, Qiao D, Yin Z, Shang L. (2017) Dual Mechanism of an Intramolecular Charge Transfer (ICT)-FRET-Based Fluorescent Probe for the Selective Detection of Hydrogen Peroxide. Chemistry, an Asian journal 12: 3187–3194.
[13] Wang Y, Cao L, Zhai Y, Yin Z, Sun Y, Shang L. (2017) Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor. Antimicrobial agents and chemotherapy 61: e00298-17.
[14] Zeng D, Zhang R, Nie Q, Cao L, Shang L, Yin Z. (2016) Discovery of 2'-α-C-Methyl-2'-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus. ACS medicinal chemistry letters 7: 1197–1201.
[15] Zhai Y, Ma Y, Ma F, Nie Q, Ren X, Wang Y, Shang L, Yin Z. (2016) Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors. European journal of medicinal chemistry 124: 559–573.
[16] Han Z, Liang X, Wang Y, Qing J, Cao L, Shang L, Yin Z. (2016) The discovery of indole derivatives as novel hepatitis C virus inhibitors. European journal of medicinal chemistry 116: 147–155.
[17] Zeng D, Ma Y, Zhang R, Nie Q, Cui Z, Wang Y, Shang L, Yin Z. (2016) Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors. Bioorganic & medicinal chemistry letters 26: 1762–1766.
[18] Han Z, Liang X, Ren X, Shang L, Yin Z. (2016) A 3,7-Dihydroxyphenoxazine-based Fluorescent Probe for Selective Detection of Intracellular Hydrogen Peroxide. Chemistry, an Asian journal 11: 818–822.
[19] Zhai Y, Zhao X, Cui Z, Wang M, Wang Y, Li L, Sun Q, Yang X, Zeng D, Liu Y, Sun Y, Lou Z, Shang L, Yin Z. (2015) Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease. Journal of medicinal chemistry 58: 9414–9420.
[20] Wang P, Zhang S, Meng Q, Liu Y, Shang L, Yin Z. (2015) Site-specific chemical modification of peptide and protein by thiazolidinediones. Organic letters 17: 1361–1364.
[21] Shang L, Zhang S, Yang X, Sun J, Li L, Cui Z, He Q, Guo Y, Sun Y, Yin Z. (2015) Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay. Antimicrobial agents and chemotherapy 59: 1827–1836.
Teaching
[1] Undergraduate: Organic Reaction of Drug Synthesis, Medicinal Chemistry and Medicinal Chemistry Experiment
[2] Master and Doctor: Drug Research and Development, Chemical Biology
