Changliang Shan
Professor
· Work Address: College of Pharmacy, Nankai University
· E-mail: changliangshan@nankai.edu.cn
Research Areas
Tumor Pharmacology and Molecular Biology, Cell Biology, Post-translational modification of metabolism
Awards
[1] 2014.09, The Science and Technology Awards of CACA (Third Prize), Chinese Anti-Cancer Association
[2] 2021.06, The 9th Mentoring Award of Nankai University
Social Service
[1] 2010, Member, Chinese Society for Cell Biology (CSCB) China
[2] 2016, Member, The Chinese Society of Biochemistry and Molecular Biology (CSBMB)
[3] 2016, Member, The Chinese Society for Immunology (CSI)
[4] 2018, Member, Chinese society of Pharmacology
[5] 2017, Committee member, Committee of Anti-Cancer Agent of China Anti-Cancer association
[6] 2017, Committee member, Tumor marker committee of China Anti-Cancer association
[7] 2017, Committee member, Chinese Society for Cancer Cell Research
[8] 2018, Committee member, Cancer metabolism committee of China Anti-Cancer association
[9] 2018, Committee member, Chinese Society for Cell metabolism
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
1. Wang J*, Chang H, Quan X, Dai X, Wang Y, Wang C, Zhang S*, Shan C*. A model for identification of potential phase-separated proteins based on protein sequence, structure and cellular distribution. Int J Biol Macromol. 2023 Jun 5:125196.
2. Xie F, Zhang H, Zhu K, Jiang CS, Zhang X, Chang H, Qiao Y, Sun M, Wang J, Wang M, Tan J, Wang T, Zhao L, Zhang Y, Lin J, Zhang C, Liu S, Zhao J*, Luo C*, Zhang S*, Shan C*. PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1. MedComm (2020). 2023 Mar 28;4(2):e245.
3. Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH*, Luo C*, Zhang S*, Shan C*. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism. Acta Pharm Sin B. 2023 Jan;13(1):157-173.
4. Wang J, Qiao Y, Sun M, Sun H, Xie F, Chang H, Wang Y, Song J, Lai S, Yang C, Li X, Liu S, Zhao X, Ni K, Meng K, Zhang S*, Shan C*, Zhang C*, FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1.Clinical and Translational Medicine.2022. DOI: 10.1002/ctm2.772
5. Sun M, Sheng H, Wu T, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S*, Shan C*, Zhang S*. PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3. Biochem Pharmacol. 2021 Oct;192:114736.
6. Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S*, Shan C*. Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1. Biochem Pharmacol. 2020 Aug;178:114092.
7. Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S*, Shan C*. YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. 2020 Jul 10;41(5):541-550.2
8. Li Y, Liang R, Sun M, Li Z, Sheng H, Wang J, Xu P, Liu S, Yang W, Lu B, Zhang S*, Shan C*. AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation. Cancer Lett. 2020 May 28;478:82-92.2
9. Shan C*,#, Lu Z, Li Z, Sheng H, Fan J, Qi Q, Liu S, Zhang S*. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death Dis. 2019 Jul 8;10(7):525.
10. Zhang S, Sheng H, Zhang X, Qi Q, Chan CB, Li L, Shan C*, Ye K*. Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell Death Dis. 2019 Mar 4;10(3):222.
11. Zheng W, Feng Q, Liu J, Guo Y, Gao L, Li R, Xu M, Yan G, Yin Z, Zhang S*, Liu S*, Shan C*. Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer. Front Pharmacol. 2017 Jun 30;8:421.eCollection 2017.
12. Wang J#, Luo C#, Shan C#, You Q#, Lu J, Elf S, Zhou Y, Wen Y, Vinkenborg JL, Fan J, Kang H, Lin R, Han D, Xie Y, Karpus J, Chen S, Ouyang S, Luan C, Zhang N, Ding H, Merkx M, Liu H, Chen J, Jiang H, He C. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79.
13. Lin R#, Elf S#, Shan C#, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.
14. Shan C#, Elf S#, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J, Chen J. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014 Aug 21;55(4):552-65.
15. Shan C, Kang HB, Elf S, Xie J, Gu TL, Aguiar M, Lonning S, Hitosugi T, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Fan J. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. J Biol Chem. 2014 Aug 1;289(31):21413- 22.
16. Fan J#, Shan C#, Kang HB#, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S, Chen J. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014 Feb 20;53(4):534-48.
17. Shan C#, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Ye L, Zhang X. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cellsfrom complement attack. Carcinogenesis. 2011, 32(8):1190-7.
18. Shan C#, Xu F. Zhang S, You J, You X, Qiu L, Zheng J, Ye L, Zhang X. Hepatitis B virus X protein promotes livercell proliferation via a positive cascade loop involving arachidonic acidmetabolism and p-ERK1/2. Cell Res. 2010, 20(5):563-75.
Grant：
1. National Nature Science Foundation of China, 81973356,The regulation and intervention of PRMT5 on ovarian cancer cell metabolism, 2020/01-2023/12, 550,000RMB, Role: Principal Investigator
2. Science and Technology Program of Guangzhou, 201807010003, Overcoming cancer cisplatin resistence by targeting metabolism enzyme 6PGD, 2018/04-2020/03, 1000,000 RMB，Role: Principal Investigator
Teaching
[1]Undergraduate: Tumor Metabolism
[2]Doctor: Pharmacology
