Yue-Ming Li
Ph. D., Professor of Medicinal Chemistry and Organic Chemistry
Work Address: College of Pharmacy, Nankai University
Telephone: +86-22-***
E-mail: ymli@nankai.edu.cn
Research Areas
Asymmetric Catalysis, Asymmetric Synthesis of Biologically Interesting Molecules, Drug Design and Synthesis.
Awards
[1] Higher Education Young Teacher Award (Fok Ying Tung Education Foundation, Ministry of Education, 1993)
[2] Excellent Text Book Award (Second Class, Ministry of Education, China, 2002)
[3] National Natural Science Award (Second Class, The State Council, China, 2005)
[4] Prominent Teacher Award (Nankai University, 2014)
[5] Prominent Teacher Award (Tianjin Commission of Education, 2020)
5. Social Service
[1]] 2018-Present, Member, Higher Education Directing Committee for Pharmacy Major, Ministry of Education
[2] Editor, Chinese Journal of Medicinal Chemistry
[3] Editor, Pharmacy Education
Research & Achievements
Monographs
[1] Lin, G.-Q.; Sun, X.-W.; Chen, Y.-Q.; Li, Y.-M.; Chan, A. S. C. Chiral Synthesis – Asymmetric Reactions and Their Applications (Fifth Edition); Science Press: Beijing, 2013.
[2] Lin, G.-Q.; Li, Y.-M.; Chen, Y.-Q.; Sun, X.-W.; Chan, A. S. C. Chiral Synthesis – Asymmetric Reactions and Their Applications (Forth Edition); Science Press: Beijing, 2010.
[3] Lin, G.-Q.; Chen, Y.-Q.; Li, Y.-M.; Chan, A. S. C. Chiral Synthesis – Asymmetric Reactions and Their Applications (Third Edition); Science Press: Beijing, 2007.
[4] Lin, G.-Q.; Li, Y.-M.; Chen, Y.-Q.; Chan, A. S. C. Chiral Synthesis – Asymmetric Reactions and Their Applications (Second Edition); Science Press: Beijing, 2005.
[5] Li, Y.-M.; Fan, Q.-H.; Chan, A. S. C. Asymmetric Organic Reactions; Chemical Industry Press: Beijing, 2005.
[6] Li, Y.-M.; Fan, Q.-H.; Chan, A. S. C. Asymmetric Organic Reactions – Recovery and Reuse of Catalysts; Chemical Industry Press: Beijing, 2003.
[7] Lin, G.-Q.; Chen, Y.-Q.; Li, Y.-M.; Chan, A. S. C. Chiral Synthesis – Asymmetric Reactions and Their Applications; Science Press: Beijing, 2002.
[8] Lin, G.-Q.; Li, Y.-M.; Chan, A. S. C. Principles and Applications of Asymmetric Synthesis; Wiley InterScience: New York, 2001.
Book Chapters
[1] Li, Y.-M.; Yu, W.-Y.; Chan, A. S. C. In Phosphorus Ligands in Asymmetric Catalysis - Synthesis and Applications; Börner, A., Ed.; Wiley-VCH: Weinheim, 2008; Vol. 1.
[2] Li, Y.-M.; Yan, M.; Chan, A. S. C. In Phosphorus Ligands in Asymmetric Catalysis - Synthesis and Applications; Börner, A., Ed.; Wiley-VCH: Weinheim, 2008; Vol. 1.
Publications
[1] Yao, C.; Chen, Y.; Sun, R.; Wang, C.; Huang, Y.; Li, L.; Li, Y.-M. “Binaphthyl–prolinol chiral ligands: design and their application in enantioselective arylation of aromatic aldehydes.” Organic & Biomolecular Chemistry 2021, 19(16), 3644-3655.
[2] Yao, C.; Wu, P.; Huang, Y.; Chen, Y.; Li, L.; Li, Y.-M. “Binaphthyl-based chiral ligands: design, synthesis and evaluation of their performance in enantioselective addition of diethylzinc to aromatic aldehydes.” Organic & Biomolecular Chemistry 2020, 18(47), 9712-9725.
[3] Yang, C.-H.; Han, M.; Li, W.; Zhu, N.; Sun, Z.; Wang, J.; Yang, Z.; Li, Y.-M. “Direct Intramolecular Aminoboration of Allenes.” Organic Letters 2020, 22(13), 5090-5093.
[4] Wang, W.-J.; Mao, L.-F.; Lai, H.-L.; Wang, Y.-W.; Jiang, Z.-B.; Li, W.; Huang, J.-M.; Xie, Y.-J.; Xu, C.; Liu, P.; Li, Y.-M.; Leung, E. L. H.; Yao, X.-J. “Dolutegravir derivative inhibits proliferation and induces apoptosis of non-small cell lung cancer cells via calcium signaling pathway.” Pharmacological Research 2020, 161, 105129.
[5] Mao, L.-f.; Wang, Y.-w.; Zhao, J.; Xu, G.-q.; Yao, X.-j.; Li, Y.-M. “Discovery of Icotinib-1,2,3-Triazole Derivatives as IDO1 Inhibitors.” Frontiers in Pharmacology 2020, 11(1480), 579024.
[6] Mao, L.; Sun, G.; Zhao, J.; Xu, G.; Yuan, M.; Li, Y.-M. “Design, synthesis and antitumor activity of icotinib derivatives.” Bioorganic Chemistry 2020, 105, 104421.
[7] Jia, Y.; Li, L.; Duan, L.; Li, Y.-M. “The aza-Prins Cyclization of Unfunctionalized Olefins Promoted by NHC-Cu Complex and ZrCl4.” Applied Organometallic Chemistry 2020, 34(11), e5927.
[8] Gao, E.; Li, Q.; Duan, L.; Li, L.; Li, Y.-M. “Isosterically Designed Chiral Catalysts: Rationale, Optimization and Their Application in Enantioselective Nucleophilic Addition to Aldehydes.” Tetrahedron 2020, 76(47), 131648.
[9] Zheng, L.-C.; Li, L.; Duan, L.; Li, Y.-M. “FeBr3-catalyzed regioselective intramolecular sulfenoamination of unactivated terminal olefins.” Tetrahedron 2019, 75(45), 130619.
[10] Xu, Z.-Q.; Zheng, L.-C.; Li, L.; Duan, L.; Li, Y.-M. “FeBr3-catalyzed regioselective hydroxysulfenylation of N-allylsulfonamides with sulfonyl hydrazides.” Tetrahedron 2019, 75(5), 643-651.
[11] Xu, Z.-Q.; Zheng, L.-C.; Li, L.; Duan, L.; Li, Y.-M. “Metal-free oxysulfonylation and aminosulfonylation of alkenyl oximes: synthesis of sulfonylated isoxazolines and cyclic nitrones.” Organic & Biomolecular Chemistry 2019, 17(4), 898-907.
[12] Xu, Z.-Q.; Wang, W.-B.; Zheng, L.-C.; Li, L.; Duan, L.; Li, Y.-M. “Iodine-mediated aminosulfonylation of alkenyl sulfonamides with sulfonyl hydrazides: synthesis of sulfonylmethyl piperidines, pyrrolidines and pyrazolines.” Organic & Biomolecular Chemistry 2019, 17(40), 9026-9038.
[13] Gao, E.; Li, M.; Duan, L.; Li, L.; Li, Y.-M. “Isosteric expansion of the structural diversity of chiral ligands: Design and application of proline-based N,N′-dioxide ligands for copper-catalyzed enantioselective Henry reactions.” Tetrahedron 2019, 75(37), 130492.
[14] Xu, Z.-Q.; Wang, C.; Li, L.; Duan, L.; Li, Y.-M. “Construction of 3,4-Dihydroisoquinolinones and Indanones via DTBP-Promoted Oxidative Coupling of N-Allylbenzamides with Aromatic Aldehydes.” The Journal of Organic Chemistry 2018, 83(17), 9718-9728.
[15] Cui, B.; Sun, H.; Xu, Y.; Li, L.; Duan, L.; Li, Y.-M. “Mn(OAc)3-Mediated Hydrotrifluoromethylation of Unactivated Alkenes Using CF3SO2Na as the Trifluoromethyl Source.” The Journal of Organic Chemistry 2018, 83(11), 6015-6024.
[16] Yang, C.-H.; Xu, Z.-Q.; Duan, L.; Li, Y.-M. “CuBr2-promoted intramolecular bromocyclization of N-allylamides and aryl allyl ketone oximes.” Tetrahedron 2017, 73(48), 6747-6753.
[17] Sun, H.; Cui, B.; Duan, L.; Li, Y.-M. “Intramolecular Aminoalkoxylation of Unfunctionalized Olefins via Intramolecular Iodoamination and Aziridinium Ion Ring-Opening Sequence.” Organic Letters 2017, 19(7), 1520-1523.
[18] Cui, B.; Sun, H.; Xu, Y.; Duan, L.; Li, Y.-M. “MgCl2-catalyzed trifluoromethylation of carbonyl compounds using (trifluoromethyl)trimethylsilane as the trifluoromethylating agent.” Tetrahedron 2017, 73(48), 6754-6762.
[19] Sun, H.; Cui, B.; Liu, G.-Q.; Li, Y.-M. “MnI2-catalyzed regioselective intramolecular iodoamination of unfunctionalized olefins.” Tetrahedron 2016, 72(45), 7170-7178.
[20] Liu, G.-Q.; Cui, B.; Xu, R.; Li, Y.-M. “Preparation of trans-2-Substituted-4-halopiperidines and cis-2-Substituted-4-halotetrahydropyrans via AlCl3-Catalyzed Prins Reaction.” The Journal of Organic Chemistry 2016, 81(12), 5144-5161.
[21] Yang, C.-H.; Zhang, Y.-S.; Fan, W.-W.; Liu, G.-Q.; Li, Y.-M. “Intramolecular Aminoboration of Unfunctionalized Olefins.” Angewandte Chemie International Edition 2015, 54(43), 12636-12639.
[22] Yang, C.-H.; Li, G.-J.; Gong, C.-J.; Li, Y.-M. “N,N-Dialkylaniline-assisted thionation of carboxylic amides and esters.” Tetrahedron 2015, 71(4), 637-642.
[23] Yang, C.-H.; Fan, W.-W.; Liu, G.-Q.; Duan, L.; Li, L.; Li, Y.-M. “On the understanding of BF3·Et2O-promoted intra- and intermolecular amination and oxygenation of unfunctionalized olefins.” RSC Advances 2015, 5(75), 61081-61093.
[24] Liu, G.-Q.; Yang, C.-H.; Li, Y.-M. “Modular Preparation of 5-Halomethyl-2-oxazolines via PhI(OAc)2-Promoted Intramolecular Halooxygenation of N-Allylcarboxamides.” The Journal of Organic Chemistry 2015, 80(22), 11339-11350.
[25] Liu, G.-Q.; Li, L.; Duan, L.; Li, Y.-M. “mCPBA-mediated metal-free intramolecular aminohydroxylation and dioxygenation of unfunctionalized olefins.” RSC Advances 2015, 5(75), 61137-61143.
[26] Li, T.-T.; Liu, G.-Q.; Wang, Y.-M.; Cui, B.; Sun, H.; Li, Y.-M. “The effect of hydrogen bond on Br➢nsted acid-catalyzed intramolecular hydroamination of unfunctionalized olefins.” Tetrahedron 2015, 71(38), 7003-7009.
[27] Wang, Y.-M.; Li, T.-T.; Liu, G.-Q.; Zhang, L.; Duan, L.; Li, L.; Li, Y.-M. “Cooperative effect in organocatalytic intramolecular hydroamination of unfunctionalized olefins.” RSC Advances 2014, 4(19), 9517-9521.
[28] Liu, G.-Q.; Li, Y.-M. “Regioselective (Diacetoxyiodo)benzene-Promoted Halocyclization of Unfunctionalized Olefins.” The Journal of Organic Chemistry 2014, 79(21), 10094-10109.
[29] Liu, G.-Q.; Ding, Z.-Y.; Zhang, L.; Li, T.-T.; Li, L.; Duan, L.; Li, Y.-M. “Regioselective Copper(II)-Mediated Bromoamination of Unfunctionalized Olefins: An Efficient Route to N-Heterocyclic Compounds.” Advanced Synthesis & Catalysis 2014, 356(10), 2303-2310.
[30] Liu, G.-Q.; Cui, B.; Sun, H.; Li, Y.-M. “Trifluoroacetic acid-promoted intramolecular hydroamination of unfunctionalized olefins bearing electron-rich amino groups.” Tetrahedron 2014, 70(35), 5696-5703.
[31] Li, W.; Liu, G.-Q.; Cui, B.; Zhang, L.; Li, T.-T.; Li, L.; Duan, L.; Li, Y.-M. “Transition metal-free iodine-promoted haloamination of unfunctionalized olefins.” RSC Advances 2014, 4(26), 13509-13513.
[32] Liu, G.-Q.; Li, W.; Li, Y.-M. “A New Method for Intramolecular Chloroamination of Unfunctionalized Olefins.” Advanced Synthesis & Catalysis 2013, 355(2-3), 395-402.
[33] Li, R.-L.; Liu, G.-Q.; Li, W.; Wang, Y.-M.; Li, L.; Duan, L.; Li, Y.-M. “One-pot preparation of 3-chloropiperidine compounds via Cu(II)-promoted intramolecular chloroamination of unfunctionalized olefins.” Tetrahedron 2013, 69(29), 5867-5873.
[34] Liu, G.-Q.; Li, W.; Wang, Y.-M.; Ding, Z.-Y.; Li, Y.-M. “Ligand acceleration in ZnI2-catalyzed intramolecular hydroamination of unfunctionalized olefins.” Tetrahedron Letters 2012, 53(33), 4393-4396.
[35] Liu, G.-Q.; Li, Y.-M. “Zinc triflate-catalyzed intermolecular hydroamination of vinylarenes and anilines: scopes and limitations.” Tetrahedron Letters 2011, 52(52), 7168-7170.
[36] Zhang, S.-L.; Huang, Z.-S.; Li, Y.-M.; Chan, A. S. C.; Gu, L.-Q. “Synthesis of zwitterionic 4-hydroxy-2(1H)-quinolinone derivatives.” Tetrahedron 2008, 64(19), 4403-4407.
[37] Ruan, J.; Lu, G.; Xu, L.; Li, Y.-M.; Chan, A. S. C. “Catalytic Asymmetric Alkynylation and Arylation of Aldehydes by an H8-Binaphthyl-Based Amino Alcohol Ligand.” Advanced Synthesis & Catalysis 2008, 350(1), 76-84.
[38] Qiu, L.; Li, Y.-M.; Kwong, F. Y.; Yu, W.-Y.; Fan, Q.-H.; Chan, A. S. C. “Highly Efficient Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids Catalyzed by Ruthenium(II)-Dipyridylphosphine Complexes.” Advanced Synthesis & Catalysis 2007, 349(4-5), 517-520.
[39] Li, Y.-M.; Kwong, F.-Y.; Yu, W.-Y.; Chan, A. S. C. “Recent advances in developing new axially chiral phosphine ligands for asymmetric catalysis.” Coordination Chemistry Reviews 2007, 251(17-20), 2119-2144.
[40] Jia, X.; Wang, L.; Chan, A. S. C.; Li, Y. “Asymmetric Hydroformylation of Styrene Catalyzed by Pyranoside Diphosphite-Rh(I) Complexes.” Chinese Journal of Catalysis 2007, 28(6), 492-494.
[41] Chan, S. H.; Lam, K. H.; Li, Y.-M.; Xu, L.; Tang, W.; Lam, F. L.; Lo, W. H.; Yu, W. Y.; Fan, Q.; Chan, A. S. C. “Asymmetric hydrogenation of quinolines with recyclable and air-stable iridium catalyst systems.” Tetrahedron: Asymmetry 2007, 18(22), 2625-2631.
[42] Zhang, S.-L.; Huang, Z.-S.; Shen, Y.-D.; Li, Y.-M.; Yao, J.-H.; Huang, M.; Chan, A. S. C.; Gu, L.-Q. “The unique regioselectivity in the formation of disubstituted-1,4-benzoquinones generated from the reaction of 4-hydroxycoumarins with 1,4-benzoquinone.” Tetrahedron Letters 2006, 47(38), 6757-6760.
[43] Qiu, L.; Kwong, F. Y.; Wu, J.; Lam, W. H.; Chan, S.; Yu, W.-Y.; Li, Y.-M.; Guo, R.; Zhou, Z.; Chan, A. S. C. “A New Class of Versatile Chiral-Bridged Atropisomeric Diphosphine Ligands: Remarkably Efficient Ligand Syntheses and Their Applications in Highly Enantioselective Hydrogenation Reactions.” Journal of the American Chemical Society 2006, 128(17), 5955-5965.
[44] Pei, L.-X.; Li, Y.-M.; Bu, X.-Z.; Gu, L.-Q.; Chan, A. S. C. “One-pot synthesis of 5,6-dihydroxylated benzo[b]furan derivatives.” Tetrahedron Letters 2006, 47(15), 2615-2618.
[45] Lu, G.; Li, X.; Li, Y.-M.; Kwong, F. Y.; Chan, A. S. C. “Highly Enantioselective Catalytic Alkynylation of Ketones - A Convenient Approach to Optically Active Propargylic Alcohols.” Advanced Synthesis & Catalysis 2006, 348(14), 1926-1933.
[46] Lu, G.; Kwong, F. Y.; Ruan, J.-W.; Li, Y.-M.; Chan, A. S. C. “Highly Enantioselective Addition of In Situ Prepared Arylzinc to Aldehydes Catalyzed by a Series of Atropisomeric Binaphthyl-Derived Amino Alcohols.” Chemistry: A European Journal 2006, 12(15), 4115-4120.
[47] Huang, S.-L.; Luo, Y.; Huang, Z.-S.; Wang, X.-Y.; Bu, X.-Z.; Liu, P.-Q.; Ma, L.; Xie, B.-F.; Liu, Z.-C.; Li, Y.-M.; Chan, A. S. C. “Synthesis and Cytotoxicity of 9-Substituted Benzo[de]chromene-7,8-dione and 5-Benzyl-9-substituted Benzo[de]chromene-7,8-dione.” Synthetic Communications 2006, 36(18), 2667-2684.
[48] Huang, S. L.; Luo, Y.; Huang, Z. S.; Bu, X. Z.; Liu, P. Q.; Ma, L.; Li, Y. M.; Chan, A. S. C.; Gu, L. Q. “The Mechanism on Cyclization, Debenzylation and Oxidation of 1-[1-(Benzyloxy)-3-methylnaphthalen-4-yloxy]propan-2-one.” Chinese Chemical Letters 2006, 17(6), 769-772.
[49] Zhou, J.-L.; Lu, Y.-J.; Ou, T.-M.; Zhou, J.-M.; Huang, Z.-S.; Zhu, X.-F.; Du, C.-J.; Bu, X.-Z.; Ma, L.; Gu, L.-Q.; Li, Y.-M.; Chan, A. S.-C. “Synthesis and Evaluation of Quindoline Derivatives as G-Quadruplex Inducing and Stabilizing Ligands and Potential Inhibitors of Telomerase.” Journal of Medicinal Chemistry 2005, 48(23), 7315-7321.
[50] Zhang, S.-L.; An, L.-K.; Huang, Z.-S.; Ma, L.; Li, Y.-M.; Chan, A. S. C.; Gu, L.-Q. “An intriguing reaction of 4-hydroxycoumarins with 2,3-dichloro-5,6-dicyanobenzoquinone.” Tetrahedron 2005, 61(12), 3087-3090.
[51] Wang, R.; Xu, L.; Ji, J.; Shi, Q.; Li, Y.; Zhou, Z.; Hong, M.; Chan, A. S. C. “Metal-Directed Stereoselective Syntheses of Homochiral Complexes of exo-Bidentate Binaphthol Derivatives.” European Journal of Inorganic Chemistry 2005, (4), 751-758.
[52] Wang, L.-L.; Guo, R.-W.; Li, Y.-M.; Chan, A. S. C. “Rhodium-catalyzed asymmetric hydroformylation of vinylarenes with novel chiral P,N-ligands derived from 1,2:5,6-di-O-cyclohexylidene-d-mannitol.” Tetrahedron: Asymmetry 2005, 16(19), 3198-3204.
[53] Shen, Y.-D.; Wu, H.-Q.; Zhang, S.-L.; Bu, X.-Z.; An, L.-K.; Huang, Z.-S.; Liu, P.-Q.; Gu, L.-Q.; Li, Y.-M.; Chan, A. S. C. “Novel synthesis of o-naphthothiophenequinone derivatives via regioselective Diels–Alder reaction.” Tetrahedron 2005, 61(38), 9097-9101.
[54] Shen, Q.; Peng, Q.; Shao, J.; Liu, X.; Huang, Z.; Pu, X.; Ma, L.; Li, Y.-M.; Chan, A. S. C.; Gu, L. “Synthesis and biological evaluation of functionalized coumarins as acetylcholinesterase inhibitors.” European Journal of Medicinal Chemistry 2005, 40(12), 1307-1315.
[55] Qi, J.-Y.; Li, Y.-M.; Zhou, Z.-Y.; Che, C.-M.; Yeung, C.-H.; Chan, A. S. C. “Novel Manganese Complex as an Efficient Catalyst for the Isobutyraldehyde-Mediated Epoxidation of Cyclic Alkenes with Dioxygen.” Advanced Synthesis & Catalysis 2005, 347(1), 45-49.
[56] Pei, L.-X.; Huang, S.-L.; Shen, Y.-D.; An, L.-Q.; Huang, Z.-S.; Li, Y.-M.; Gu, L.-Q.; Bu, X.-Z.; Chan, A. S. C. “Synthesis of novel dihydrofuro[b]-pyridinone derivatives: oxidation coupling of 3-hydroxy-4(1H)-pyridinone with β-dicarbonyl compounds.” Tetrahedron Letters 2005, 46(30), 5085-5088.
[57] Lu, G.; Li, Y.-M.; Li, X.-S.; Chan, A. S. C. “Synthesis and application of new chiral catalysts for asymmetric alkynylation reactions.” Coordination Chemistry Reviews 2005, 249(17–18), 1736-1744.
[58] Kwong, F. Y.; Li, Y. M.; Lam, W. H.; Qiu, L.; Lee, H. W.; Yeung, C. H.; Chan, K. S.; Chan, A. S. C. “Rhodium-Catalyzed Asymmetric Aqueous Pauson-Khand-Type Reaction.” Chemistry: A European Journal 2005, 11(13), 3872-3880.
[59] Kwong, F. Y.; Lee, H. W.; Qiu, L.; Lam, W. H.; Li, Y.-M.; Kwong, H. L.; Chan, A. S. C. “Rhodium-BisbenzodioxanPhos Complex-Catalyzed Homogeneous Enantioselective Pauson-Khand-Type Cyclization in Alcoholic Solvents.” Advanced Synthesis & Catalysis 2005, 347(14), 1750-1754.
[60] An, L. K.; Bu, X. Z.; Huang, Z. S.; Ma, L.; Gu, L. Q.; Chan, A. S. C.; Li, Y. M. “Synthesis of New Benzoimidazole Derivatives.” Chinese Chemical Letters 2005, 16(1), 7-10.
[61] Zhang, S.-L.; Huang, Z.-S.; An, L.-K.; Bu, X.-Z.; Ma, L.; Li, Y.-M.; Chan, A. S. C.; Gu, L.-Q. “Synthesis of Zwitterionic 4-Hydroxycoumarin Derivatives through a Unique Reaction of 4-Hydroxycoumarins with p- Benzoquinone and Pyridine.” Organic Letters 2004, 6(26), 4853-4855.
[62] Yi, B.; Fan, Q.-H.; Deng, G.-J.; Li, Y.-M.; Qiu, L.-Q.; Chan, A. S. C. “Novel Chiral Dendritic Diphosphine Ligands for Rh(I)-Catalyzed Asymmetric Hydrogenation: Remarkable Structural Effects on Catalytic Properties.” Organic Letters 2004, 6(9), 1361-1364.
[63] Wang, R.; Xu, L.; Li, X.; Li, Y.; Shi, Q.; Zhou, Z.; Hong, M.; Chan, A. S. C. “New Types of Homochiral Helical Coordination Polymers Constructed by exo-Bidentate Binaphthol Derivatives.” European Journal of Inorganic Chemistry 2004, (8), 1595-1599.
[64] Wang, L.; Li, Y.-M.; Yip, C.-w.; Qiu, L.; Zhou, Z.; Chan, A. S. C. “Synthesis of New Chiral Aryl Diphosphite Ligands Derived from Pyranoside Backbone of Monosacharides and Their Application in Copper-Catalyzed Asymmetric Conjugate Addition of Diethylzinc to Cyclic Enones.” Advanced Synthesis & Catalysis 2004, 346(8), 947-953.
[65] Shi, Q.; Xu, L.; Ji, J.; Li, Y.; Wang, R.; Zhou, Z.; Cao, R.; Hong, M.; Chan, A. S. C. “Syntheses and structures of two anion-templated dinuclear cadmium complexes with diamino-binaphthyl Schiff bases as ligands.” Inorganic Chemistry Communications 2004, 7(12), 1254-1257.
[66] Liang, L.; Yan, M.; Li, Y.-M.; Chan, A. S. C. “Highly enantioselective copper-catalyzed 1,4-conjugate addition of diethylzinc to cyclic enones and α,β-unsaturated lactones.” Tetrahedron: Asymmetry 2004, 15(16), 2575-2578.
[67] Jia, X.; Li, X.; Xu, L.; Li, Y.; Shi, Q.; Au-Yeung, T. T.-L.; Yip, C. W.; Yao, X.; Chan, A. S. C. “Titanium-Catalyzed Tandem Sulfoxidation-Kinetic Resolution Process: A Convenient Method for Higher Enantioselectivities and Yields of Chiral Sulfoxide.” Advanced Synthesis & Catalysis 2004, 346(7), 723-726.
[68] Huang, Z.-S.; Wu, H.-Q.; Duan, Z.-F.; Xie, B.-F.; Liu, Z.-C.; Feng, G.-K.; Gu, L.-Q.; Chan, A. S. C.; Li, Y.-M. “Synthesis and cytotoxicity study of alkannin derivatives.” European Journal of Medicinal Chemistry 2004, 39(9), 755-764.
[69] Chen, X.; Guo, R.; Li, Y.; Chen, G.; Yeung, C.-H.; Chan, A. S. C. “Application of phosphinous amide ligands in palladium complex-catalyzed asymmetric allylic alkylation: influence of steric effects on enantioselectivity.” Tetrahedron: Asymmetry 2004, 15(2), 213-217.
[70] Chen, Y.-X.; Li, Y.-M.; Lam, K.-H.; Chan, A. S. C. “Novel Chiral Aminophosphine Ligand: Synthesis and Application in Asymmetric Catalytic Hydrogenation Reaction.” Chinese Journal of Chemistry 2003, 21(1), 66-70.
[71] Cai, Y.-P.; Su, C.-Y.; Chen, C.-L.; Li, Y.-M.; Kang, B.-S.; Chan, A. S. C.; Kaim, W. “Formation of Racemate and Mesocate Complexes from an Achiral Tripodal Ligand Containing Three Benzimidazole Groups.” Inorganic Chemistry 2003, 42(1), 163-168.
[72] Pai, C.-C.; Li, Y.-M.; Zhou, Z.-Y.; Chan, A. S. C. “Synthesis of new chiral diphosphine ligand (BisbenzodioxanPhos) and its application in asymmetric catalytic hydrogenation.” Tetrahedron Letters 2002, 43(15), 2789-2792.
[73] Fan, Q.-H.; Li, Y.-M.; Chan, A. S. C. “Recoverable Catalysts for Asymmetric Organic Synthesis.” Chemical Reviews 2002, 102(10), 3385-3466.
[74] Chen, Y.-X.; Li, Y.-M.; Lam, K.-H.; Chan, A. S. C. “New Chiral Ligand N-Toluenesulfonyl-2,2'-dimethoxy-6,6'-di-aminobiphenyl for Catalytic Asymmetric Transfer Hydrogenation of Ketones.” Chinese Journal of Chemistry 2002, 20(6), 606-609.
[75] Xing, Q.-Y.; Wang, H.-Z.; Zhou, X.; Jin, S.; Li, Y.-M.; Chan, A. S. C. “A study of the reaction between 2,4-disubstituted-2,3-dihydro-1,5-benzothiazepines and ketenes generated in situ from chloro and dichloroacetyl chlorides.” Journal of Heterocyclic Chemistry 2001, 38(3), 561-567.
[76] Wang, H.-Z.; Zhou, X.; Xu, J.-X.; Jin, S.; Li, Y.-M.; Chan, A. S. C. “On the mechanism and stereochemistry of the formation of β-lactam derivatives of 2,4-disubstituted-2,3-dihydro-benzo[1,4]diazepines.” Journal of Heterocyclic Chemistry 2001, 38(5), 1031-1034.
[77] Chen, Y.-X.; Li, Y.-M.; Lam, K.-H.; Chan, A. S. C. “Synthesis of Novel Chiral Biphenylamine Ligand 6,6'-Dimethoxy-2,2'-diaminobiphenyl.” Chinese Journal of Chemistry 2001, 19(8), 794-799.
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Teaching (Undergraduate level)
[1] Organic Chemistry
[2] Introduction to Drug Research
[3] Drugs and Human Health
[4] Science Fiction and Innovation
Teaching (Master level)
Advanced Drug Design and Synthesis
Teaching (Ph.D. master level)
Advanced Organic Chemistry
