Yuanyuan Hou
Professor
· Work Address: College of Pharmacy, Nankai University
· Telephone: +86-22-23506290
· E-mail: houyy@nankai.edu.cn
Research Areas
Chemical composition analysis and mechanism of action of TCM
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
[1] Liqiang Wang, Jiamin Peng, Xin Wang, Xiaodan Zhu, Binfeng Cheng, Jie Gao, Min Jiang, Gang Bai, Hou Yuanyuan*. (2012) Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats. Die Pharmazie 67(2): 168-173.
[2] Yuanyuan Hou, Xuelin Cao, Linyi Dong, Liqiang Wang, Binfeng Cheng, Qian Shi, Xiaodong Luo*, Gang Bai*. (2012) Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β2AR agonist identification in alkaloidal extract of Alstonia scholaris. Journal of Chromatography A 1227: 203-209.
[3] Binfeng Cheng, Yuanyuan Hou*, Liqiang Wang, Linyi Dong, Jiamin Peng, Gang Bai. (2012) Dual-bioactivity-based liquid chromatography-coupled quadrupole time-of-flight mass spectrometry for NF-κB inhibitors and β2AR agonists identification in Chinese Medicinal Preparation Qingfei Xiaoyan Wan. Analytical and Bioanalytical Chemistry 404: 2445-2452.
[4] Xue Xiao1, Yuanyuan Hou1, Jun Du, Yang Liu, Yanjie Liu, Linyi Dong, Qionglin Liang, Yiming Wang, Gang Bai, Guoan Luo*. (2012) Determination of Main Categories of Components in Corn Steep Liquor by Near-Infrared Spectroscopy and Partial Least-Squares Regression. Journal of Agricultural and Food Chemistry 60: 7830-7835.
[5] Qian Shi1, Yuanyuan Hou1, Jie Hou, Penwei Pan, Ze Liu, Min Jiang, Jie Gao, Gang Bai*. (2012) Glycyrrhetic acid synergistically enhances β2-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. PLoS One 7(9): e44921.
[6] Yuanyuan Hou1, Xuelin Cao1, Liqiang Wang, Binfeng Cheng, Linyi Dong, Xiaodong Luo, Gang Bai*, Wenyuan Gao*. (2012) Microfractionation bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry for the identification of nuclear factor-κB inhibitors and β2 adrenergic receptor agonists in an alkaloidal extract of the folk herb Alstonia scholaris. Journal of Chromatography B 908: 98-104.
[7] Ya-Nan Wang1, Yuan-Yuan Hou1, Ming-Zhu Sun1, Chun-Yang Zhang, Gang Bai*, Xin Zhao*, Xi-Zeng Feng*. (2014) Behavioural screening of zebrafish using neuroactive traditional Chinese medicine prescriptions and biological targets. Scientific Reports 4: 5311.
[8] Yuanyuan Hou, Binfeng Cheng, Mengge Zhou, Runping Fang, Min Jiang, Wenbin Hou, Gang Bai*. (2014) Searching for Synergistic Bronchodilators and Novel Therapeutic Regimens for Chronic Lung Diseases from a Traditional Chinese Medicine, Qingfei Xiaoyan Wan. PLoS One 9 (11): e113104.
[9] Dan Sun, Mengge Zhou, Xuhui Ying, Binfeng Cheng, Yanqi Han, Yan Nie, Yuanyuan Hou* and Gang Bai. (2014) Identification of nuclear factor-κB inhibitors in the folk herb Rhizoma Menispermi via bioactivity-based ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry analysis. BMC Complementary and Alternative Medicine 14: 356.
[10] Jiajia Wang, Yan Nie, Yunjuan Li, Yuanyuan Hou*, Wei Zhao, Jiagang Deng, Peng George Wang, and Gang Bai. (2015) Identification of Target Proteins of Mangiferin in Mice with Acute Lung Injury Using Functionalized Magnetic Microspheres Based on Click Chemistry. Journal of Agricultural and Food Chemistry 63: 10013-10021.
[11] Guoyu Ding, Yan Nie, Yuanyuan Hou*, Zenghui Liu, Aina Liu, Jiamin Peng, Min Jianga, Gang Bai*. (2015) An integrated strategy of marker ingredients searching and near infrared spectroscopy rapid evaluation for the quality control of Chinese eaglewood. Journal of Pharmaceutical and Biomedical Analysis 114: 462-470.
[12] Runping Fang, Qingxin Cui, Jixue Sun, Xixi Duan, Xiaoyao Ma, Weiya Wang, Binfeng Cheng, Yang Liu, Yuanyuan Hou*, Gang Bai. (2015) PDK1/Akt/PDE4D axis identified as a target for asthma remedy synergistic with β2 AR agonists by a natural agent arctigenin. Allergy 70: 1622-1632.
[13] Jin Tao, Yan Nie, Yuanyuan Hou*, XiaoyaoMa, Guoyu Ding, Jie Gao,Min Jiang, Gang Bai*. (2016) Chemomics-Integrated Proteomics Analysis of Jie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury in Mice. Evidence-Based Complementary and Alternative Medicine Article ID 7379146.
[14] Jin Tao, Yuanyuan Hou*, Xiaoyao Ma, Dan Liu, Yongling Tong, Hong Zhou, Jie Gao, Gang Bai*. (2016) An integrated global chemomics and system biology approach to analyze the mechanisms of the traditional Chinese medicinal preparation Eriobotrya japonica-Fritillaria usuriensis dropping pills for pulmonary diseases. BMC Complementary and Alternative Medicine 16(1): 4.
[15] Yuan Yuan Hou, Yan Nie, Bin Feng Cheng, Jin Tao, Xiao Yao Ma, Min Jiang, Jie Gao, Gang Bai*. (2016) Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways. Acta Pharmaceutica Sinica B 6(3): 212-221.
[16] Guoyu Ding, Yuanyuan Hou*, Jiamin Peng, Yunbing Shen, Min Jiang, Gang Bai. (2016) On-line near-infrared spectroscopy optimizing and monitoring biotransformation process of γ-aminobutyric acid. Journal of Pharmaceutical Analysis 6: 171-178.
[17] Dan Sun, Yanqi Han, Weiya Wang, Zengyong Wang, Xiaoyao Ma, Yuanyuan Hou*, Gang Bai. (2016) Screening and Identification of Caulis Sinomenii Bioactive Ingredients with Dual-target NF-κB Inhibition and ß2-AR Agonizing Activities. Biomedical Chromatography 30(11):1843-1853.
[18] Guoyu Ding, Baiqing Li, Yanqi Han, Aina Liu, Jingru Zhang, Jiamin Peng, Min Jiang,Yuanyuan Hou*, Gang Bai*. (2016) A rapid integrated bioactivity evaluation system based onnear-infrared spectroscopy for quality control of Flos Chrysanthemi. Journal of Pharmaceutical and Biomedical Analysis 131: 391-399.
[19] Zhongyao Tang, Yuanyuan Hou*, Xueyan Hu, Aina Liu, Leefong Yau, Tiantian Tong, Zhihong Jiang, Gang Bai. (2017) Metabolite identification and pharmacokinetic study of platycodi radix (Jiegeng) in vivo. RSC Advances 7: 37459-37466.
[20] Qingxin Cui1, Yuanyuan Hou1, Yanan Wang, Xu Li, Yang Liu, Xiaoyao Ma, Zengyong Wang, Weiya Wang, Jin Tao, Qian Wang, Min Jiang, Dongyan Chen, Xizeng Feng*, Gang Bai*. (2017) Biodistribution of arctigenin‑loaded nanoparticles designed for multimodal imaging. Journal of Nanobiotechnology 15: 27.
[21] Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen, Man Zhang, Quandeng Nie, Yuanyuan Hou*, Gang Bai*. (2017) Ursolic Acid, A Natural Nutraceutical Agent, Targets Caspase3 and Alleviates Inflammation-Associated Downstream Signal Transduction. Molecular Nutrition & Food Research 61(12): 1700332.
[22] Xueyan Hu, Yunbing Shen, Shengnan Yang, Wei Lei, Cheng Luo, Yuanyuan Hou*, Gang Bai*. (2018) Metabolite identification of ursolic acid in mouse plasma and urine after oral administration by ultra-high performance liquid chromatography/quadrupole time-of flight mass spectrometry. RSC Advances 8: 6532-6539.
[23] Guangcui Chu, Dandan Cheng, Wenjuan Liu, Xuefeng Wang, Xiaotao Hou, Yuanyuan Hou*, Hongjun Wei*, Jiagang Deng, Gang Bai. (2018) Screening and evaluation of antioxidants from lees by micro-injector systems combined with a fluorescent probe, N-borylbenzyloxycarbonyl-3,7-dihydroxyphenoxazine, in living Drosophila. Chinese Chemical Letters 29: 1521-1527.
[24] Shengnan Yang, Yuan Zhang, Fukui Shen, Xiaoyao Ma, Man Zhang, Yuanyuan Hou*, Gang Bai*. (2019) The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation. FEBS Letters 593 (2): 175-186.
[25] Fukui Shen, Wenbo Wu, Man Zhang, Zhongyao Tang, Hao Huang, Jingrong Wang, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. (2019) Micro-PET imaging demonstrates 3-O-β-D-glucopyranosyl platycodigenin as an effective metabolize improves the dosimetry of [18F]-Phillygenin in lung tissue. Frontiers in Pharmacology 10: 1020.
[26] Yuan Zhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, Xueyan Hu, Jin Tao, Yuanyuan Hou*, Gang Bai*. (2019) Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins. Acta Pharmaceutica Sinica B 9 (2): 294-303.
[27] Yunbing Shen, Shengnan Yang, Xueyan Hu, Man Zhang, Xiaoyao Ma, Zhihua Wang, Yuanyuan Hou*, Gang Bai*. (2019) Natural product puerarin activates Akt and ameliorates glucose and lipid metabolism dysfunction in hepatic cells. Journal of Functional Foods 55: 296-304.
[28] Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Ming Jiang, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. (2019) Quantitative proteomics combine with affinity MS revealed the molecular mechanism of ginsenoside anti-tumor effects. Journal of Proteome Research 18 (5): 2100-2108.
[29] Zhihua Wang, Unchol Kim, Jinbiao Liu, Chuanjing Cheng, Wenbo Wu, Shuang Guo, Yunjiang Feng, Ronald J. Quinn, Yuanyuan Hou*, Gang Bai*. (2019) Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbs. Analytical and Bioanalytical Chemistry 411(22): 5785-5797.
[30] Yanting Jiao, Fukui Shen, Zhihua Wang, Lili Ye, Man Zhang, Jie Gao, Yuanyuan Hou*, Gang Bai*. (2019) Genipin, a natural AKT inhibitor, targets the PH domain to affect downstream signaling and alleviates inflammation. Biochemical Pharmacology 170, 113660.
[31] Xiaoyao Ma, Aina Liu, Wenjuan Liu, Zhihua Wang, Nianwei Chang, Suyun Li, Jiansheng Li, Yuanyuan Hou*, Gang Bai*. (2019) Analyze and identify Peiminine target EGFR improve lung function and alleviate pulmonary fibrosis to prevent exacerbation of COPD by phosphoproteomics analysis. Frontiers in Pharmacology 10: 737.
[32] Weiyi Zhang, Jie Gao, Man Zhang, Wenjuan Liu, Xiaoyao Ma, Wei Lei, Xiaotao Hou, Erwei Hao, Yuanyuan Hou*, Gang Bai*. (2020) Cinnamaldehyde enhances anti-melanoma activity through covalently binding ENO1 and have synergy effects with dacarbazine. Cancers 12: 311.
[33] Man Zhang, Xiaoyao Ma, Honglei Xu, Wenbo Wu, Xiaoying Wang, Min Jiang, Yuanyuan Hou* Gang Bai*. (2020) A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibits downstream signaling, and alleviates inflammation. FEBS Journal 287: 1816-1829.
[34] Chuanjing Cheng, Fukui Shen, Guoyu Ding, Aina Liu, Simeng Chu, Yuejiao Ma, Xiaotao Hou, Erwei Hao, Xiaoying Wang, Yuanyaun Hou*, Gang Bai*. (2020) Lepidiline A improves the balance of endogenous sex hormones and increases fecundity by targeting HSD17B1. Molecular Nutrition & Food Research, 2020, 64: 1900706.
[35] Zhihua Wang, Wenbo Wu, Chenxiang Guan, Shuang Guo, Chaowen Li, Ruixue Niu, Jie Gao, Min Jiang, Liping Bai, Elaine Laihan Leung, Yuanyuan Hou*, Zhihong Jiang*, Gang Bai*. (2020) 20(s)-Protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumor network via multiomic analysis. Acta Pharmaceutica Sinica B 10(6): 1020-1035.
[36] Weiyi Zhang, Jie Gao*, Fukui Shen, Xiaoyao Ma, Zhihua Wang, Xiaotao Hou, Erwei Hao, Yuanyuan Hou*, Gang Bai*. (2020) Cinnamaldehyde changes the dynamic balance of glucose metabolism by targeting ENO1. Life Science 258:118151.
[37] Man Zhang, Lili Ye, Wenbo Wu, Kaixin Liu, Hao Huang, Dandan Cheng, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. (2020) Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhances cell membrane permeability, promotes antibiotic pulmonary targeting and improves anti-infect efficacy. Journal of Nanobiotechnology 18: 140.
[38] Chuan-jing Cheng, Xiao-tao Hou, Er-wei Hao, Nut Palachai, Jintanaporn Wattanathorn, Gang Bai, Yuan-yuan Hou*. (2021) Integrated Molecular Network and HPLC-UV-FLD Analysis to Explore Antioxidant Ingredients in Camellia Nitidissima Chi. Journal of Food Science 86: 1396-1305.
[39] Ge Fang, Chuanjing Cheng, Manqian Zhang, Xiaoyao Ma, Shengnan Yang, Xiaotao Hou, Jiagang Deng, Yuanyuan Hou*, Gang Bai*. (2021) The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism. Journal of Functional Foods 82: 104501.
[40] Xiaoyao Ma, Man Zhang, Ge Fang, Chuanjing Cheng, Mukuo Wang, Yiman Han, Xiaotao Hou, Erwei Hao, Yuanyuan Hou*, Gang Bai. (2021) Ursolic acid reduces hepatocellular apoptosis and alleviates alcohol-induced liver injury via irreversible inhibition of CASP3 in vivo. Acta Pharmacologica Sinica 42: 1101-1110.
Teaching
[1] Undergraduate: Pharmaceutical Analysis
[2] Master: Modern Analysis Techniques of TCM
