Bai Gang
Professor
· Work Address: College of Pharmacy, Nankai University
· Telephone: +86-22-23506792
· E-mail: gangbai@nankai.edu.cn
Research Areas
Systems biology and chemical biology for TCM, Intelligent evaluation of TCM quality
Awards
5. Social Service
[1] 2015-Present, Member, World Federation of Chinese Medicine Societies (WFCMS), Professional Committee of Network Pharmacology & TCM Analysis
[2] 2016-Present, Member, China Association of TCM (CATCM), Product Development and Cultivation Committee & Respiratory medicine research
[3] 2019-Present, Member, Special Committee of TCM and Natural Product of China Pharmaceutical Societies
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
[1] Zheng W, Gao J, Zhang M, Liu W, Ma X, Lei W, Hou X, Hao E, Hou Y*, Bai G*. (2020) Cinnamaldehyde enhances anti-melanoma activity through covalently binding ENO1 and have synergy effects with dacarbazine. Cancer 12: 311.
[2] Wang Z, Wu W, Leung E, Guan C, Guo S, Li C, Niu R, Jiang M, Hou Y*, Jiang Z*, Bai G*. (2020) 20(S)-Protopanaxatriol promotes the binding of P53 and DNA to regulate the antitumor network via multiomic analysis. Acta Pharmaceutica Sinica B 10(6):1020-1035.
[3] Cheng C, Shen F, Ding G, Liu A, Chu S, Ma Y, Hou X, Hao E, Wang X, Hou Y*, G Bai*. (2020) Lepidiline A Improves the Balance of Endogenous Sex Hormones and Increases Fecundity by Targeting HSD17B1. Molecular Nutrition & Food Research 64:19007062020.
[4] Chu S, Liu W, Lu Y, Yan M, Guo Y, Chang N, Jiang M*, Bai G*. (2020) Sinigrin Enhanced Anti-asthmatic Effects of beta-Adrenergic Receptors Agonists by Regulating cAMP-Mediated Pathways. Frontiers in Pharmacology 11:723.
[5] Zhang M, Ma X, Xu H, Wu W, Wang X, Jiang M; Hou Y*, Bai G*. (2020) A natural AKT inhibitor swertiamarin that targets the AKT-PH domain inhibits downstream signaling and alleviates inflammation. FEBS Journal 287(9):1816-1829.
[6] W Zhang, Gao J, Shen F, Ma X, Wang Z, Hou X, Hao E, Hou Y, Bai G*. (2020) Cinnamaldehyde changes the dynamic balance of glucose metabolism by targeting ENO1. Life sciences 258: 118151.
[7] Zhang M, Ye L, Huang H, Cheng D, Wu W, Liu K, Jiang Z, Hou Y*, Bai G*. (2020) Micelles self-assembled by 3-O-β-D-glucopyranosyl latycodigenin enhances cell membrane permeability, promotes antibiotic pulmonary targeting and improves anti-infect efficacy. Journal of Nanobiotechnology 18:140.
[8] Chang N, Gao J, Niu L, Hou Y, Jiang M*, Bai G*. (2020) Integrated artificial neural network analysis and functional cell based affinity mass spectrometry for screening a bifunctional activator of Ca2+ and β2AR in Aconite. Journal of Pharmaceutical and Biomedical Analysis 190: 113506.
[9] Yang S, Zhang Y, Shen F, Ma X, Zhang M, Hou Y*, Bai G*. (2019) The flavonoid baicalin improves glucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3β phosphorylation. FEBS Letters 593: 175-186.
[10] Shen Y, Yang S, Hu X, Zhang M, Ma X, Wang Z, Hou Y*, Bai G*. (2019) Natural Product Puerarin Activates Akt and Ameliorates Glucose and Lipid Metabolism Dysfunction in Hepatic Cells. Journal of Functional Foods 55: 296-304.
[11] Zhang Y, Wang Z, Ma X, Yang S, Hu X, Hou Y*, Bai G*. (2019) Glycyrrhetinic acid binds to the conserved P-loop region and interferes with the interaction of RAS-effector proteins. Acta Pharmaceutica Sinica B 9(2):294-303.
[12] Zhang Y, Yang S, Zhang M, Wang Z, He X, Hou Y, Bai G*. (2019) Glycyrrhetinic acid improves insulin resistance by regulating the balance between the Ras/MAPK and PI3K/Akt pathways. Nutrients 11:604.
[13] Lu Y, Liu W, Zhang M, Deng Y, Jiang M*, Bai G*. (2019) The Screening Research of NF-κB inhibitors from Moutan Cortex Based on Bioactivity-integrated UPLC-Q/TOF-MS. Evidence-based Complementary and Alternative Medicine 2019, 6150357.
[14] Ni J, Guo Y, Chang N, Yan M, Cheng D, Jiang M*, Bai G*. (2019) Effect of N-methyltyramine on the regulation of adrenergic receptors via enzymatic epinephrine synthesis for the treatment of gastrointestinal disorders. Biomedicine & Pharmacotherapy 111:1393-1398.
[15] Z Wang, Kim U, Jiao Y, Li C, Guo Y, Ma X, Jiang M, Jiang Z, Hou Y*, Bai G*. (2019) Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects. Journal of Proteome Research 18:2100-2108.
[16] Lu Y, Deng Y, Liu W, Jiang M*, Bai G*. (2019) Searching for Calcium Antagonists for Hypertension Disease Therapy from Moutan Cortex, using Bioactivity Integrated UHPLC-Q/TOF-MS. Phytochemical analysis 30:456-4632019.
[17] Ma X, Liu A, Liu W, Wang Z, Chang N, Li S, Li J, Hou Y*, Bai G*. (2019) Analyze and identify Peiminine target EGFR improve lung function and alleviate pulmonary fibrosis to prevent exacerbation of COPD by phosphoproteomics analysis. Frontiers in Pharmacology 10:737.
[18] W Liu, Y Lu, S Chu, M Jiang*, G Bai*. (2019) Phillygenin, a lignan compound, inhibits hypertension by reducing PLCβ3-dependent Ca2+ oscillation. Journal of Functional Foods 60:103432.
[19] Wang Z, Kim U, Liu J, Cheng C, Wu W, Guo S, Feng Y, Quinn R, Hou Y*, Bai G*. (2019) Comprehensive TCM molecular networking based on MS/MS in silico spectra with integration of virtual screening and affinity MS screening for discovering functional ligands from natural herbs. Analytical and Bioanalytical Chemistry 411(22):5785–5797.
[20] Lei W, Deng Y, Ma X, Ni J, Jiang M*, Bai G*. (2019) Phthalides, senkynolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, by suppressing CD137 expression. Biomedicine & Pharmacotherapy 117:109074.
[21] Shen F, Wu W, Zhang M, Tang Z, Huang H, Wang J, Jiang Z, Hou Y*, Bai G*. (2019) Micro-PET Imaging Demonstrates 3-O-β-D-Glucopyranosyl Platycodigenin as an Effective Metabolite Affects Permeability of Cell Membrane and Improves Dosimetry of [18F]-Phillygenin in Lung Tissue. Frontiers in Pharmacology 10:1020.
[22] Jiao Y, Shen F, Wang Z, Ye L, Hou Y*, Bai G*. (2019) Genipin, a natural AKT inhibitor, targets the PH domain to inhibit inflammation. Biochemical Pharmacology 170: 113660.
[23] Bai G, Zhang T, Hou Y, Ding G, Jiang M, Luo G. (2018) From quality markers to data mining and intelligence assessment: A smart quality-evaluation strategy for traditional Chinese medicine based on quality markers. Phytomedicine 44,109-116.
[24] Hu X, Shen Y, Yang S, Lei W, Luo C, Hou Y*, Bai G*. (2018) Metabolite identification of ursolic acid in mouse plasma and urine after oral administration by ultrahigh performance liquid chromatography/quadrupole time-of-flight mass spectrometry. RSC Advances 8:6532-6539.
[25] Lei W, Ni J, Xia X, Jiang M*, Bai G*. (2018) Searching for synergistic calcium antagonists and novel therapeutic regimens for coronary heart disease therapy from a Traditional Chinese Medicine, Suxiao Jiuxin Pill. Journal of chromatography B 1092:220-227.
[26] Chu G, Cheng D, Liu W, Wang X, Hou X, Hou Y*, Wei H*, J Deng, G Bai. (2018) Screening and evaluation of antioxidants from lees by micro-injector systems combined with a fluorescent probe, N-borylbenzyloxycarbonyl-3, 7-dihydroxyphenoxazine, in living Drosophila. Chinese chemical letters 29: 1521-1527.
[27] Cui Q, Liu Y, Zhou M, Han Y, Yin C, Bai G*. (2018) An optimized MicroPET imaging method for the distribution and synergies of natural products. Frontiers in Pharmacology 9:948.
[28] Gao J, He X, Ma Y, Zhao X, Hou X, Hao E, Deng J, Bai G*. (2018) Chlorogenic Acid Targeting of the AKT-PH Domain Activates AKT-GSK3β/FOXO1 Signaling and Improves Glucose/Lipid Metabolism. Nutrients 10:1366.
Teaching
[1] Undergraduate: Pharmaceutical Analysis
[2] Master: Systematic biology of Traditional Chinese medicine
Modern Analysis of Traditional Chinese medicine
[2] Doctor: Medicinal Chemical Biology
