Chenggang Li

Publisher：Dates：2021-11-09Views：

Curriculum Vitae

Chenggang Li, Ph.D.

Senior Research Fellow

State Key Laboratory of Medicinal Chemical Biology & College of Pharmacy,

Nankai University, Tianjin, China 300350

Mobile +86 17720137434

LICHENGGANG@NANKAI.EDU.CN

 

Research Areas

To study mechanism of tumorigenesis regulated by abnormal glucose/lipid signatures, I developed mouse models with tumor-burden of cultured cells/patient-derived tissues with abnormal metabolic profiling that reflect human clinical symptoms.

During my postdoc training in Harvard Medical School/Brigham and Women’s Hospital and University of Cincinnati, I discovered that abnormal bio-lipids metabolism including prostaglandin and sphingosine biosynthesis, play crucial roles in tumorigenesis of TSC disorders. Furthermore，dysregulated glucose metabolic signaling synergistically facilitate this process. Therefore, works point to potential molecular and pharmaceutic approaches that could further improve outcomes for theses clinically important malignant disorders.

My career objective is to conduct an independent translational research on cancers and associated organs/tissues injury, so that explore new therapeutic strategies.

 

Education

2007-2011  PhD. in Molecular Biology and Biochemistry, Peking Union Medical College, Beijing, China

2000-2007  BS, MD, MS in Medicine, Harbin Medical University, Harbin, China

 

Employment

1.     Jun/2017-present  Senior Research Fellow, State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China

2.     Jun/2015-Feb/2017  Research Scientist (Staff), Pulmonary, Critical Care and Sleep Medicine Division, Department of Internal Medicine, University of Cincinnati, Cincinnati, USA

3. Jun/2011-Jun/2015  Post-doctoral fellow, Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women’s Hospital/Harvard Medical School, Boston, USA

 

Research & Achievements

  1. Chenggang Li, Po-Shun Lee, Yang Sun, Xiaoxiao Gu, Erik Zhang, Yanan Guo,      Chin-Lee Wu, Neil Auricchio, Carmen Priolo, Jing Li, Alfredo Csibi, Andrey      Parkhitko, Tasha Morrison, Anna Planaguma, Shamsah Kazani, Elliot Israel,      Kai-Feng Xu, Elizabeth Petri Henske, John Blenis, Bruce Levy, David      Kwiatkowski, Jane Yu. Estradiol      and mTORC2 cooperate to enhance prostaglandin biosynthesis and      tumorigenesis in tuberous sclerosis complex. The Journal of Experimental Medicine      (JEM). 2014 Jan 13;211(1):15-28 PMID: 24395886, PMCID:      PMC3892971

  2. Chenggang Li, Penghui Yang, Yang Sun, Taisheng Li, Zhong Wang, Zhen Zou,      Chen Wang, Zhongwei Chen, Li Xing, Chong Tang, Xiangwu Ju, Feng Guo,      Jiejie Deng, Yan Zhao, Yiwu Yan, Peng Yang, Jun Tang, Zhinan Yin,      Dangsheng Li, Bin Cao, Chen Wang, Xiliang Wang, Chengyu Jiang. IL-17      response mediates acute lung injury induced by the 2009 Pandemic Influenza      A (H1N1) Virus. Cell Research. 2011:      1-11. PMID: 22025253  PMCID: PMC3292301

  3. Sun Y, Guo F, Zou Z, Li C (co-first author), Hong X,      Zhao Y, Wang C, Wang H, Liu H, Yang P, Han Z, Liu K, Kuba K, Song B, Gao      J, Mo Z, Li D, Li B, Li Q, Zhong N, Wang C, Penninger JM, Jiang      C. Cationic nanoparticles directly bind angiotensin-converting enzyme      2 and induce acute lung injury in mice. Particle and Fibre Toxicology 12 (4)  

  4. Yang Sun, Chenggang      Li (co-1st author), Yuelong Shu, Xiangwu Ju, Zhen Zou,      Hongliang Wang, Shuan Rao, Feng Guo, Haolin Liu, Wenlong Nan, Yan Zhao,      Yiwu Yan, Jun Tang, Chen Zhao, Peng Yang, Kangtai Liu, Shunxin Wang,      Huijun Lu, Xiao Li, Lei Tan, Rongbao Gao, Jingdong Song, Xiang Gao, Xinlun      Tian, Yingzhi Qin, Kai-Feng Xu, Dangsheng Li, Ningyi Jin, and Chengyu      Jiang. Inhibition of autophagy ameliorates acute lung injury caused by      avian influenza A H5N1 infection. SCIENCE      SIGNALING. 2012 Feb 21;5(212):ra16. PMID: 22355189

  5. Chenggang Li，Haolin Liu， Yang Sun， Hongliang Wang， Feng Guo， Shuan Rao， Jiejie Deng， Yanli Zhang，Yufa Miao， Chenying Guo， Jie Meng， Xiping Chen， Limin Li， Dangsheng Li， Haiyan Xu， Heng Wang， Bo Li， Chengyu Jiang. PAMAM      Nanoparticles Promote Acute Lung Injury by Inducing Autophagic Cell Death      through the Akt-TSC2-mTOR Signaling Pathway. JOURNAL      OF MOLECULAR CELL BIOLOGY. 2009 (1), 37-45,      PMID: 19516051.

  6. Chenggang Li, Xiaolei Liu, Yang Liu, Erik Zhang, Kantha Medepalli, Kohei      Masuda, Na Li, Elizabeth Kopras, David Kwiatkowski, Michael Borchers,      Kathryn Wikenheiser-Brokamp, Andrew Osterburg, Maxwell Mays, Yang Sun,      David Plas, Julia Sun, David Franz, Jamie Capal, Anya Alayev, Marina Holz,      Darcy Krueger, Brian Siroky, and Jane Yu. Tuberin Regulates Prostaglandin      Receptor-mediated Viability, via Rheb, in mTORC1-hyperactive Cells. Molecular Cancer Research.      2017 Jul 14. doi: 10.1158/1541-7786.MCR-17-0077.

  7. Chenggang Li, Xiaobo Zhou, Yang Sun, Erik Zhang, John D Mancini, Andrey      Parkhitko, Tasha A Morrison, Edwin K Silverman, Elizabeth P Henske, Jane J      Yu. Faslodex Inhibits Estradiol-induced ECM Dynamics and Lung Metastasis      in a Model of LAM. Am J Respir Cell Mol Biol.      2013 Jul;49(1):135-42. PMID: 23526212.

  8. Chenggang Li, Erik Zhang, Yang Sun, Po-Shun Lee, Yongzhong Zhan, Yanan Guo,      Juan C. Osorio, Ivan O. Rosas, Kai-Feng Xu, David J. Kwiatkowski and Jane      J. Yu. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2      in tuberous sclerosis complex and lymphangioleiomyomatosis. PLoS One.      2014 Oct 27;9(10):e104809. doi: 10.1371/journal.pone.0104809.

  9. Chenggang Li, Penghui Yang, Yanli Zhang, Yang Sun, Wei Wang, Zhen Zou, Li      Xing, Zhongwei Chen, Chong Tang, Feng Guo, Jiejie Deng, Yan Zhao, Yiwu      Yan, Jun Tang, Xiliang Wang, Chengyu Jiang. Corticosteroid Treatment      Ameliorates Acute Lung Injury Induced by 2009 Swine Origin Influenza A      (H1N1).PLoS One.      2012;7(8):e44110. Epub 2012 Aug 29.PMID: 22952892 PMCID: PMC3430649

  10. Penghui Yang,      Jiejie Deng, Chenggang Li (co-1st author), Peirui Zhang,      Li Xing, Zhiwei Li, Wei Wang, Yan Zhao, Yiwu Yan, Hongjing Gu, Xin Liu,      Zhongpeng Zhao, Shaogeng Zhang, Xiliang Wang, Chengyu Jiang.      Characterization of the 2009 Pandemic A/Beijing/501/2009 H1N1 Influenza      Strain in Human Airway Epithelial Cells and Ferrets. PLoS One. 2012 7(9):      e46184. PMC3458874

  11. Li C, Li N, Liu X, Zhang E, Sun Y,      Masuda K, Li J, Sun J, Morrison T, Li X, Chen Y, Wang J, Karim N, Zhang Y,      Blenis J, Reginato M, Henske E and Yu J. Proapototic protein Bim      attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. JCI insight. 2016 Nov 17;1(19):e86629.