Professor and Deputy Director of the Department of Pharmacology
· Work Address: State Key Laboratory of Medicinal Chemical Biology
· Telephone: +86-22-135 1292 2691
· E-mail: tao.sun@nankai.edu.cn
Research Areas
Basic research: Aiming at the molecular mechanism of epithelial-mesenchymal transition in malignant tumors, it is proposed that "epithelial-endothelial transition" is the formation mechanism of angiogenic mimicry.
New anti-tumor therapy technology: established and designed an anti-tumor strategy for artificial circular DNA to up-regulate the expression of tumor suppressor genes.
New drug research and development and transformation: systematically studied doxycycline as an "old drug for new use" and relocated to PAR1-positive malignant tumors, inhibiting proliferation, metastasis and EMT, and through preclinical research, safety evaluation research and pharmaceutical research.
Awards
[1] 2011, the Chinese Medical Association, the first "Outstanding Youth Award for Pathological Research"
[2] 2012, Ministry of Education, National Hundred Excellent Doctoral Dissertations
[3] 2013, Tianjin, Tianjin Science and Technology System Outstanding Youth
[4] 2015, Tianjin City, Youth May 4th Medal
[5] 2016, Tianjin, the first batch of young top-notch talents
[6] 2017, Tianjin, the young talents of science and technology innovation promotion plan
[7] 2018, Nankai University, the 8th "Good Teacher and Helpful Friend" Top Ten Award
[8] 2019, Tianjin City, Outstanding Youth Science Foundation
Social Service
[1] Member of Chinese Society of Cell Biology, Director of Tianjin Society of Cell Biology;
[2] Member of the Tumor Microenvironment Academic Committee of the Chinese Anti-Cancer Association
[3] Member of Tianjin Science and Technology Association
[4] Leader of the Biomedicine Group of Tianjin Youth Science and Technology Workers Association
[5] Reviewer of Hepatology，Cell Death & Different，Theranostics，Oncogene，JCMM
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
[1] Meng J, Liu Y, Han J, Tan Q, Chen S, Qiao K, Zhou H, Sun T*, Hsp90β promoted endothelial cell-dependent tumor angiogenesis in hepatocellular carcinoma. Mol Cancer.2017 Mar 31;16(1):72
[2] Meng, J., Chen, S., Han, J., Tan, Q., Wang, X., Wang, H., Zhong, W., Qin, Y., Qiao, K., Zhang, C., Gao, W., Lei, Y., Liu, H., Liu, Y., Zhou, H., Sun, T.*, Yang, C.*, Derepression of co-silenced tumor suppressor genes by nanoparticle-loaded circular ssDNA reduces tumor malignancy. Science translational medicine 2018, 10 (442).
[3] Zhang, H., Chang, Z., Qin, L.-n., Liang, B., Han, J., Qiao, K., Yang, C., Liu, Y. *, Zhou, H..*, Sun, T.*, MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells. Signal Transduction and Targeted Therapy 2021, 6 (1), 135.
[4] Sun, T., Sun, B.*, Zhao, X., Zhao, N., Dong, X., Che, N., Yao, Z., Ma, Y., Gu, Q., Zong, W., Liu, Z., Promotion of tumor cell metastasis and vasculogenic mimicry by way of transcription coactivation by Bcl-2 and Twist1: a study of hepatocellular carcinoma. Hepatology (Baltimore, Md.) 2011, 54 (5), 1690-706.
[5] Sun, T., Zhao, N., Zhao, X., Gu, Q., Zhang, S., Che, N., Wang, X., Du, J., Liu, Y., Sun, B.*, Expression and functional significance of Twist1 in hepatocellular carcinoma: its role in vasculogenic mimicry. Hepatology (Baltimore, Md.) 2010, 51 (2), 545-56.
[6] Liu, H., Yang, J., Zhang, Y., Han, J., Yang, Y., Zhao, Z., Dai, X., Wang, H., Ding, X., Liu, Y., Zhong, W., Gao, W.*, Sun, T.*, Psychologic Stress Drives Progression of Malignant Tumors via DRD2/HIF1α Signaling. Cancer research 2021, 81 (20), 5353-5365.
[7] Han, J., Meng, J., Chen, S., Wang, X., Yin, S., Zhang, Q., Liu, H., Qin, R., Li, Z., Zhong, W., Zhang, C., Zhang, H., Tang, Y., Lin, T., Gao, W., Zhang, X., Yang, L., Liu, Y., Zhou, H. G., Sun, T.*, Yang, C.*, YY1 Complex Promotes Quaking Expression via Super-Enhancer Binding during EMT of Hepatocellular Carcinoma. Cancer research 2019, 79 (7), 1451-1464.
[8] Meng, J., Chen, S., Han, J., Qian, B., Wang, X., Zhong, W., Qin, Y., Zhang, H., Gao, W., Lei, Y., Yang, W., Yang, L., Zhang, C., Liu, H., Liu, Y., Zhou, H., Sun, T.*, Yang, C.*, Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma. Cancer research 2018, 78 (15), 4150-4162.
[9] Liu, H., Qin, Y., Li, K., Li, M., Yang, J., Tao, H., Tang, Y., Yang, L., Chen, S., Liu, Y., Yang, C.*, Gao, W.*, Sun, T.*, Potential type 2 diabetes mellitus drug HMPA promotes short-chain fatty acid production by improving carbon catabolite repression effect of gut microbiota. British journal of pharmacology 2021, 178 (4), 946-963.
[10] Qiao, K., Liu, Y., Xu, Z., Zhang, H., Zhang, H., Zhang, C., Chang, Z., Lu, X., Li, Z., Luo, C., Liu, Y., Yang, C., Sun, T.*, RNA m6A methylation promotes the formation of vasculogenic mimicry in hepatocellular carcinoma via Hippo pathway. Angiogenesis 2021, 24 (1), 83-96.
Clinical trial approval (IND)
[1] CFDA clinical trial approval, doxycycline treats malignant tumors (2016L03513)
[2] CFDA clinical trial approval, doxycycline treats pulmonary fibrosis (2017L01323)
Teaching
[1] Undergraduate: Introduction to Pharmacy
[2] Undergraduate: Pathology and Pathophysiology
[3] Postgraduate: Molecular Pharmacology
[4] Postgraduate: Introduction to Pharmacology
