Zhi-Song Zhang
Professor
· Work Address: College of Pharmacy, Nankai University
· Telephone: +86-22-85358010
· E-mail: zzs@nankai.edu.cn
Research Areas
Tumor microenvironment, Cell signaling transduction, Oncological Pharmacology
Awards
[1]2018.02, Science Research Famous Achievement Award in Higher Institution (2nd Prize), Ministry of Education of the People's Republic of China.
[2]2018.12, Chinese medical science and Technology Award (3rd Prize), Chinese Medical Association.
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author, #First author)
1) Gao S, Zhang LS, Wang L, Xiao NN, Long H, Yin YL, Yang YM, Xi Z, Li LY* and Zhang ZS*. RHBDF1 promotes AP-1-activated endothelial-mesenchymal transition in tumor fibrotic stroma formation. Signal Transduct Target Ther. 2021 Jul 19;6(1):273.
2) Zhang LS, Xu HL, Xia Y, Bi JP, Zhang CZ, Xi Z, Li LY, Zhang ZS*. Real-time monitoring of caspase-3/8 activity by self-assembling nanofiber probes in living cells. Chem Commun (Camb). 2021 Jan 18;57(6):797-800.
3) Zhang LS, Yin YL, Wang L, Xia Y, Ryu S, Xi Z, Li LY*, Zhang ZS*. Self-assembling nitrilotriacetic acid nanofibers for tracking and enriching His-tagged proteins in living cells. J Mater Chem B. 2021 Jan 7;9(1):80-84.
4) Zhang LS, Yan LX, Gao S, Long H, Xi Z, Li LY, Zhang ZS*. Self-assembling peptide-etoposide nanofibers for overcoming multidrug resistance. Chem Commun (Camb). 2020 Dec 18;56(97):15321-15324.
5) Ding Y, Gao S, Shen J, Bai T, Yang M, Xu S, Gao Y, Zhang Z*, Li LY*. TNFSF15 facilitates human umbilical cord blood haematopoietic stem cell expansion by activating Notch signal pathway. J Cell Mol Med. 2020 Oct;24(19):11146-11157.
6) Guo Y, Wang J, Zhou K, Lv J, Wang L, Gao S, Keller ET, Zhang ZS*, Wang Q*, Yao Z*. Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC. FASEB J. 2020 Jun;34(6):7927-7940.
7) Li J, Bai TR, Gao S, Zhou Z, Peng XM, Zhang LS, Dou DL, Zhang ZS*, Li LY*. Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression. EBioMedicine. 2018 Oct;36:229-240.
8) Guo Y#, Zhang Z#, Wei H, Wang J, Lv J, Zhang K, Keller ET, Yao Z, Wang Q. Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis. J Pathol. 2017 Oct;243(2):208-219.
9) Yang GL, Zhao Z, Qin TT, Wang D, Chen L, Xiang R, Xi Z, Jiang R, Zhang ZS*, Zhang J, Li LY*. TNFSF15 inhibits VEGF-stimulated vascular hyperpermeability by inducing VEGFR2 dephosphorylation. FASEB J. 2017 May;31(5):2001-2012.
10) Xu LX, Grimaldo S, Qi JW, Yang GL, Qin TT, Xiao HY, Xiang R, Xiao Z, Li LY*, Zhang ZS*. Death receptor 3 mediates TNFSF15- and TNFα-induced endothelial cell apoptosis. Int J Biochem Cell Biol. 2014 Oct;55:109-18.
11) Zhou Z#, Liu F#, Zhang ZS#, Shu F, Zheng Y, Fu L, Li LY. Human rhomboid family-1 suppresses oxygen-independent degradation of hypoxia-inducible factor-1α in breast cancer. Cancer Res. 2014 May 15;74(10):2719-30.
12) Qi JW, Qin TT, Xu LX, Zhang K, Yang GL, Li J, Xiao HY, Zhang ZS*, Li LY*. TNFSF15 inhibits vasculogenesis by regulating relative levels of membrane-bound and soluble isoforms of VEGF receptor 1. Proc Natl Acad Sci U S A. 2013 Aug 20;110(34):13863-8.
13) Lu Y#, Zhang Z#, Yan Z, Chen L, Deng W, Lotze M, Wang Z, Lin X, Li LY. Recombinant GnRH-p53 protein sensitizes breast cancer cells to 5-fluorouracil-induced apoptosis in vitro and in vivo. Apoptosis. 2013 Oct;18(10):1214-23.
14) Zhang Z, Li LY. TNFSF15 Modulates Neovascularization and Inflammation. Cancer Microenviron. 2012 Dec;5(3):237-47.
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Teaching
[1]Undergraduate: Cell Biology
[2]Master: Oncological Pharmacology
