Honggang Zhou
Professor
·Work Address: College of Pharmacy, Nankai University
·Telephone: +86-22-15022206769
·E-mail: honggang.zhou@nankai.edu.cn
Research Areas
1. Research on the development of anti-pulmonary fibrosis drugs and the pathogenic mechanism of idiopathic pulmonary fibrosis.
2. Construction of organ fibrosis screening and evaluation system and evaluation of active lead compounds.
3. Construction of evaluation system for diseases related to respiratory system and immune inflammation and evaluation of active lead compounds.
4. Targeted anti-tumor drug development and anti-tumor pharmacological mechanism research.
Awards
[1] 2018.10, The second level title of Tianjin "131" Innovative Talent Cultivation Project
[2] 2020.11, Advanced Instructor of Students' Innovation and Entrepreneurship, Nankai University
[3] 2021.04, "Zhiben Scholarship" Research Award, School of Pharmacy, Nankai University
[4] 2021.04, "Zhiben Scholarship" National Innovation and Entrepreneurship Award, School of Pharmacy, Nankai University
[5] 2021.04, "Zhiben Scholarship" Management Service and Public Service Award, School of Pharmacy, Nankai University
Social Service
[1] 2021.05-present, Member, Chinese Biophysical Society
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
ØOrgan fibrosis:
[1].Xiaohe Li†, Rui Liu†, Yunyao Cui†, Jingjing Liang†, Zhun Bi†, Shimeng Li, Yang Miao, Liang Zhang, Xiaoping Li, Honggang Zhou* and Cheng Yang. Protective Effect of Remdesivir Against Pulmonary Fibrosis in Mice. Frontiers in Pharmacology, 2021.
[2].Xiaohe Li†, Yunqian Zhai†, Buri Xi†, Wei Ma†, Jianwei Zhang, Xiaoyang Ma, Yang Miao, Yongjian Zhao, Wen Ning*, Honggang Zhou* and Cheng Yang. Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF‐β1 Signaling Pathway. Biomolecules, 2021.
[3].Xiaohe Li†, Yanhua Wang†, Jingjing Liang†, Zhun Bi†, Hao Ruan†, Yunyao Cui, Ling Ma, Yuli Wei, Bingchen Zhou, Liang Zhang, Honggang Zhou*, Cheng Yang*. Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway. Phytotherapy Research, 2021.
[4].Xiaohe Li†, Kai Huang†, Xiaowei Liu†, Hao Ruan†, Ling Ma, Jingjing Liang, Yunyao Cui, Yanhua Wang, Shuyang Wu, Hailong Li, Yuli Wei, Zeping Li, Jingjing Gao, Bo Yang, Xiaoping Li, Guang Yang*, Honggang Zhou* and Cheng Yang*. Ellagic Acid Attenuates BLM-Induced Pulmonary Fibrosis via Inhibiting Wnt Signaling Pathway. Frontiers in Pharmacology, 2021.
[5].Xiaohe Li†, Ling Ma†, Kai Huang†, Yuli Wei, Shida Long, Qinyi Liu, Deqiang Zhang, Shuyang Wu, Wenrui Wang, Guang Yang*, Honggang Zhou* and Cheng Yang*. Regorafenib-Attenuated Bleomycin-Induced Pulmonary Fibrosis by Inhibiting the TGF-β1 Signaling Pathway. International Journal of Molecular Sciences, 2021.
[6].Hailong Li, Rui Liu, Ruotong Zhang, Shanshan Zhang, Yiying Wei, Liang Zhang, Honggang Zhou* and Cheng Yang*. Protective Effect of Arbidol Against Pulmonary Fibrosis and Sepsis in Mice. Frontiers in Pharmacology, 2021.
[7].Xiaohe Li†, Xiaowei Liu†, Ruxia Deng†, Shaoyan Gao†, Qiuyan Jiang, Rui Liu, Hailong Li, Yang Miao, Yunqian Zhai, Shanshan Zhang, Zhenzhen Wang, Yimeng Ren, Wen Ning, Honggang Zhou*, Cheng Yang*. Betulinic acid Attenuated Bleomycin-induced Pulmonary Fibrosis by Effectively Intervening Wnt/β-catenin Signaling. Phytomedicine, 2021.
[8].Xiaohe Li, Yinshan Fang, Dingyuan Jiang, Yingying Dong, Yingying Liu, Si Zhang, Jiasen Guo, Chao Qi, Chenjing Zhao, Fangxin Jiang, Yueyue Jin, Jing Geng, Cheng Yang, Hongkai Zhang, Bin Wei, Jiurong Liang, Chen Wang, Huaping Dai, Honggang Zhou*, Dianhua Jiang* and Wen Ning*. Targeting FSTL1 for Multiple Fibrotic and Systemic Autoimmune Diseases. Molecular Therapy, 2021.
[9].Xiaohe Li†, Haiyan Yu†, Lu Liang†, Zhun Bi†, Yanhua Wang†, Shaoyan Gao, Mukuo Wang, Hailong Li, Yang Miao, Ruxia Deng, Ling Ma, Jiaoyan Luan, Shuangling Li, Menghan Liu, Jianping Lin*, Honggang Zhou*, Cheng Yang*. Myricetin ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β signaling via targeting HSP90β. Biochemical Pharmacology, 2020.
[10].Xiaohe Li†, Shuaibo Shao†, Hailong Li†, Zhun Bi†, Shanshan Zhang, Yiying Wei, Jiakun Bai, Ruotong Zhang, Xiaoyang Ma, Bowei Ma, Liang Zhang, Chunfeng Xie, Wen Ning, Honggang Zhou *, Cheng Yang *. Byakangelicin protects against carbon tetrachloride–induced liver injury and fibrosis in mice. Journal of Cellular and Molecular Medicine, 2020.
[11].Xiaohe Li†, Xiaowei Liu†, Ruxia Deng†, Shaoyan Gao†, Haiyan Yu, Kai Huang, Qiuyan Jiang, Rui Liu, Xiaoping Li, Liang Zhang, Honggang Zhou*, Cheng Yang*. Nintedanib inhibits Wnt3a-induced myofibroblast activation by suppressing the Src/β-catenin pathway. Frontiers in Pharmacology, 2020.
[12].Xiaohe Li†, Maodun Xie†, Cheng Lu†, Jiahe Mao†, Yuting Cao†, Yuyu Yang, Yujiao Wei, Xinhua Liu, Sheng Cao, Yang Song , Junya Peng , Yunyun Zhou , Qiuyan Jiang , Gang Lin , Shuanglin Qin , Min Qi , Min Hou *, Xiang Liu *, Honggang Zhou *, Guang Yang *, Cheng Yang *. Design and synthesis of Leukotriene A4 hydrolase inhibitors to alleviate idiopathic pulmonary fibrosis and acute lung injury. European Journal of Medicinal Chemistry, 2020.
[13].Xiaohe Li†, Zhun Bi†, Shuaishuai Liu†, Shaoyan Gao, Yunyao Cui, Kai Huang, Mengying Huang, Jiahe Mao, Lixin Li, Jingjing Gao, Tao Sun*, Honggang Zhou*，Cheng Yang*. Antifibrotic Mechanism of Cinobufagin in Bleomycin-Induced Pulmonary Fibrosis in Mice. Frontiers in Pharmacology, 2019.
[14].Xiaohe Li†, Cheng Lu†, Shuangwei Liu†, shuaishuai Liu†, Chengcheng Su, Ting Xiao, Zhun Bi, Pengzhen Sheng , Mengying Huang, Xinhua Liu, Yujiao Wei, Lin Zhao, Shengxiang Miao, Jiahe Mao, Kai Huang, Shaoyan Gao, Ning Liu, Min Qi , Tongtong Liu, Shuanglin Qin, Luqing Wei, Tao Sun, Wen Ning, Guang Yang*, Honggang Zhou*, Cheng Yang*. Synthesis and discovery of a drug candidate for treatment of idiopathic pulmonary fibrosis through inhibition of TGF-beta1 pathway. European Journal of Medicinal Chemistry, 2018.
[15].Xiaohe Li†, Ting Xiao†, Jiahuan Yang, Yuan Qin, Jingjing Gao, Huijuan Liu and Honggang Zhou*. Parthenolide attenuated bleomycin-induced pulmonary fibrosis via the NF-κB/Snail signaling pathway. Respiratory Research, 2018.
ØCancer:
[1].Heng Zhang, Zhi Chang, Luning Qin, Bin Liang, Jingxia Han, Kailiang Qiao, Cheng Yang, Yan-rong Liu*, Hong-gang Zhou* and Tao Sun*. MTA2 triggered R-loop trans-regulates BDH1-mediated β-hydroxybutyrylation and potentiates propagation of hepatocellular carcinoma stem cells. Signal Transduction and Targeted Therapy, 2021.
[2].Shijiao Cai, Yunpeng Bai , Huan Wang , Zihan Zhao , Xiujuan Ding , Heng Zhang , Xiaoyun Zhang ,Yantao Liu, Yan Jia, Yinan Li , Shuang Chen , Honggang Zhou* , Huijuan Liu *, Cheng Yang* and Tao Sun*. Knockdown of THOC1 reduces the proliferation of hepatocellular carcinoma and increases the sensitivity to cisplatin. Journal of Experimental & Clinical Cancer Research, 2020.
[3].Hui-Juan Liu†, Yuan Qin†, Zi-Han Zhao†, Yang Zhang†, Jia-Huan Yang, Deng-Hui Zhai, Fang Cui, Ce Luo, Man-Xi Lu, Piao-Piao Liu, Heng-Wei Xu, Kun Li, Bo Sun, Shuang Chen, Hong-Gang Zhou*, Cheng Yang* and Tao Sun*. Lentinan-functionalized Selenium Nanoparticles target Tumor Cell Mitochondria via TLR4/TRAF3/MFN1 pathway. Theranostics, 2021.
[4].Heng Zhang, Wei-long Zhong, Bo Sun, Guang Yang, Yan-rong Liu, Bi-jiao Zhou,1,2 Xin Chen, Xiang-yan Jing, Long-cong Huai, Ning Liu, Zhi-yuan Zhang, Mi-mi Li, Jing-xia Han, Kai-liang Qiao, Jing Meng, Hong-gang Zhou* Shuang Chen* Cheng Yang* and Tao Sun*. Targeted Drug-Loaded Chemical Probe Staining Assay to Predict Therapy Response and Function as an Independent Pathological Marker. iScience, 2019.
[5].Jing Meng†, Xiaoyu Ai†, Yueyang Lei†, Weilong Zhong†, Baoxin Qian, Kailiang Qiao, Xiaorui Wang, Bijiao Zhou, Hongzhi Wang, Longcong Huai, Xiaoyun Zhang, Jingxia Han, Yinyin Xue, Yuan Liang, Honggang Zhou*, Shuang Chen*, Tao Sun*, Cheng Yang*. USP5 promotes epithelial–mesenchymal transition by stabilizing SLUG in hepatocellular carcinoma. Theranostics, 2019.
ØImmune inflammatory diseases:
[1].Ting Xiao†, Mengqi Cui†, Caijuan Zheng†, Ming Wang†, Ronghao Sun†, Dandi Gao, Jiali Bao, Shanfa Ren, Bo Yang, Jianping Lin, Xiaoping Li, Dongmei Li*,Cheng Yang* and Honggang Zhou*. Myricetin Inhibits SARS-CoV-2 Viral Replication by Targeting Mpro and Ameliorates Pulmonary Inflammation. Frontiers in Pharmacology, 2021.
[2].Ting Xiao†, Yuli Wei†, Mengqi Cui†, Xiaohe Li†, Hao Ruan†, Liang Zhang, Jiali Bao, Shanfa Ren, Dandi Gao, Ming Wang, Ronghao Sun, Mingjiang Li, Jianping Lin, Dongmei Li*, Cheng Yang*, Honggang Zhou*. Effect of dihydromyricetin on SARS-CoV-2 viral replication and pulmonary inflammation and fibrosis. Phytomedicine, 2021.
[3].Wenhua Gan†, Xiaohe Li†, Yunyao Cui†, Ting Xiao, Rui Liu, Ming Wang, Yiying Wei, Mengqi Cui, Shanfa Ren, Kaiyue Helian, Wen Ning, Honggang Zhou,* Cheng Yang,* . Pinocembrin relieves lipopolysaccharide and bleomycin induced lung inflammation via inhibiting TLR4-NF-κB-NLRP3 inflammasome signaling pathway. International Immunopharmacology, 2021.
[4].Hailong Li†, Yiying Wei†, Xiaohe Li†, Shanshan Zhang, Ruotong Zhang, Jinhe Li, Bowei Ma, Shuaibo Shao, Ziwei Lv, Hao Ruan, Honggang Zhou* and Cheng Yang. Diosmetin has therapeutic efficacy in colitis regulating gut microbiota, inflammation, and oxidative stress via the circ-Sirt1/Sirt1 axis. Acta Pharmacologica Sinica, 2021.
[5].Xiaohe Li†, Buri Xi†, Yang Miao, Xiaoyang Ma, Jianwei Zhang, Jingjing Gao, Wenguo Wei, Honggang Zhou*, Cheng Yang*. Nintedanib ameliorates imiquimod-induced psoriasis in mice by inhibiting NF-κB and VEGFR2 signaling. International Immunopharmacology, 2021.
Teaching
[1] Undergraduate: Microbiology
[2] Undergraduate: Social and Administrative Pharmacy
[3] Undergraduate: Introduction to Pharmacy
