Weicheng Zhang
Associate Professor
· Work Address: College of Pharmacy, Nankai University
· E-mail: zhangweicheng@nankai.edu.cn
Research Areas
Medicinal chemistry of natural product based anticancer drugs
Research & Achievements
Peer-Reviewed Journal Papers: (*Corresponding author)
(1) Yang, Z.; Xu, X.; Yang, C.-H.; Tian, Y.; Chen, X.; Lian, L.; Pan, W.; Su, X.; Zhang, W.*; Chen, Y.* Total synthesis of Nannocystin A. Org. Lett. 2016, 18, 5768-5770.
(2) Tian, Y.; Xu, X.; Ding, Y.; Hao, X.; Bai, Y.; Tang, Y.; Zhang, X.; Li, Q.; Yang, Z.; Zhang, W.*; Chen, Y.* Synthesis and biological evaluation of nannocystin analogues toward understanding the binding role of the (2R,3S)-Epoxide in nannocystin A. Eur. J. Med. Chem. 2018, 150, 626-632.
(3) Tian, Y.; Ding, Y.; Xu, X.; Bai, Y.; Tang, Y.; Hao, X.; Zhang, W.*; Chen, Y.* Total synthesis and biological evaluation of nannocystin analogues modified at the polyketide phenyl moiety. Tetrahedron Lett. 2018, 59, 3206-3209.
(4) Tian, Y.; Wang, J.; Liu, W.; Yuan, X.; Tang, Y.; Li, J.; Chen, Y.*; Zhang, W.* Stereodivergent total synthesis of Br-nannocystins underpinning the polyketide (10R,11S) configuration as a key determinant of potency. J. Mol. Struct. 2019, 1181, 568-578.
(5) Zhang, W.* From target-oriented to motif-oriented: a case study on nannocystin total synthesis. Molecules 2020, 25, 5327.
(6) Zhang, W.* Heck macrocyclization in natural product total synthesis. Nat. Prod. Rep. 2021, 38, 1109-1135.
Teaching
[1]Undergraduate: English of pharmaceutical sciences
[2]Master: Advanced drug design and synthesis
