Guang Yang

Publisher:Dates:2021-11-05Views:

  GUANG YANG

  Associated Professor

·Work Address:  College of Pharmacy, Nankai University

·E-mail: guang.yang@nankai.edu.cn

Research Areas

Organic chemistry

Medicinal chemistry

Chemical biology

Research & Achievements (2016-2021)

30. Kun Zhang, Wei Song, Mingming Wei, Yue Sun, Ning Wang, Lan Ma, Xuan Yu, Ruolin Gao, Ruonan Wang, Yan Zhang, Nan Zheng, Ning Li, Linrong Mu, Zhiwen Tang, Xuechun Li, Cheng Yang, * Guang Yang* J. Med. Chem., 2021, DOI: 10.1021/acs.jmedchem.1c01123. ASAP.

29. Sheng Cao, Lan Ma, Yulin Liu, Mingming Wei, Yuhong Yao, Chen Li, Ruonan Wang, Ning Liu, Zhiqiang Dong, Xuechun Li, Ming Li, Xiaoji Wang, Cheng Yang,* Guang Yang* J. Med. Chem., 2021, DOI: 10.1021/acs.jmedchem.1c00996. ASAP

28. C. Li, Y. Huang, S. Cao, Y. Luo, Y. Zhang and G. Yang, Org. Chem. Front., 2021, DOI: 10.1039/D1QO01190A, ASAP.

27. Mingming Wei, Yunyun Zhou, Chong Li, Yuyu Yang, Tongtong Liu, Yulin Liu, Yujiao Wei,Ning Liu, Shuangwei Liu, Qianqian Wang, Sheng Cao, Yue Sun, Pengzhen Sheng, Cheng Lu, Cheng Yang,* Xiang Liu,* and Guang Yang * J. Med. Chem. 2021, 64, 12537−12547.

26. Yujiao Wei, Yanting Tang, Yunyun Zhou, Yuyu Yang, Yetong Cui, Xuan Wang, Yubo Wang, Yulin Liu, Ning Liu, Qianqian Wang, Chong Li, Hao Ruan, Honggang Zhou, Mingming Wei,* Guang Yang,* Cheng Yang* J. Med. Chem. 2021, 64, 9078−9099.

25. Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang,* Cheng Yang,* Li Yu* Clinical Science 2021, 135, 1751–1765.

24. Wang, J.; Sun, T.; Meng, Z.; Wang, L.; Li, M.; Chen, J.; Qin, T.; Yu, J.; Zhang, M.; Bie, Z.; Dong, Z.; Jiang, X.; Lin, L.; Zhang, C.; Liu, Z.; Jian, R.; Yang, G.;* Li, L.;* Zhang, Y.;* Huang, D. * Cancer Lett. 2021, 503, 197-212.

23. Yubo Wang, Yuanyuan Zhou, Sheng Cao, Yue Sun, Zhiqiang Dong, Chen Li, Haoran Wang, Yuhong Yao, Haiyan Yu, Xiangyi Song, Jiefu Wang, * Mingming Wei, * Guang Yang * Cheng Yang In vitro and In vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC). Bioorg. Chem. 2021, 111, 104833.

22. Zhong Weilong, Sun Bo, Ruan Hao, Qian Baoxin, Yang Guang, Cao Hailong, He Lingfei, Fan Yunjing, Roberts Arthur G., Liu Xiang, Hu Xuejiao, Liang Yuan, Ye Qing, Yin Tingting, Wang Bangmao,* Yang Cheng,* Sun Tao,* Zhou Honggang.* Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function., iScience, 2020, 23, 101464-101472.

21. Wang Xiaoji, Luo Yunhao, Qin Shuanglin, Sun Yue, Wang Ning, Yan Jun,* Yang Guang* Rh-Catalyzed diastereo- and linear-selective alpha-allylation of chiral cycloenamines, Org. Chem. Front., 2020, 7, 3715-3719.

20. Wei Mingming, Zhao Rui, Cao Yuting, Wei Yujiao, Li Ming, Dong Zhiqiang, Liu Yulin, Ruan Hao, Li Ying, Cao Sheng, Tang Zhiwen, Zhou Yuanyuan, Song Wei, Wang Yubo, Wang Jiefu, * Yang Cheng, * Yang, Guang * First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo., Eur. J. Med. Chem. 2021, 209, 112903.

19. Wang Jingya, Sun Tao, Meng Zhaoting, Wang Liuchun, Li Mengjie, Chen Jinliang, Qin Tingting, Yu Jiangyong, Zhang Miao, Bie Zhixin, Dong Zhiqiang, Jiang Xiangli, Lin Li, Zhang Cuicui, Liu Zhujun, Jiang Richeng, Yang Guang, * Li Lin, * Zhang Yan, * Huang Dingzhi * XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a, Can. Lett., 2021, 503, 197-212.

18. Wei Mingming, Xie  Maodun, Zhang Zhen, Wei Yujiao, Zhang Juan, Pan Hongli, Li Benlong, Wang Jingjing, Song Yang, Chong Chuangke, Zhao Rui, Wang Jiefu,* Yu Li,* Yang  Cheng,* Yang, Guang*  Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer, Eur. J. Med. Chem. 2020, 206, 112677.

17. Mingming Wei, Maodun Xie, Zhen Zhang, Yujiao Wei, Juan Zhang, Hongli Pan, Benlong Li, Jingjing Wang, Yang Song, Chuangke Chong, Rui Zhao, Jiefu Wang,* Li Yu,* Guang Yang,* Cheng Yang* Eur. J. Med. Chem. 2020, 206, 2020, 112677.

16. Shuanglin Qin, Linbin Yao, Yunhao Luo, Tongtong Liu, Jiayuan Xu, Yue Sun, Ning Wang, Jun Yan, Bencan Tang,* Guang Yang,* Cheng Yang* Org. Chem. Front., 2020, 7,

3132(Cover Story).

15. Xiaohe Li, Maodun Xie, Cheng Lu, Jiahe Mao, Yuting Cao, Yuyu Yang, Yujiao Wei, Xinhua Liu, Sheng Cao, Yang Song, Junya Peng, Yunyun Zhou, Qiuyan Jiang, Gang Lin, Shuanglin Qin, Min Qi, Min Hou,* Xiang Liu,* Honggang Zhou,* Guang Yang, * Cheng Yang * Eur. J. Med. Chem. 2020, 203, 112614-112624.

14. Shuanglin Qin, Yuting Cao, Yunhao Luo, Shende Jiang, J. Stephen Clark, Xiaoji Wang,* Guang Yang * Helv. Chim. Acta 2019, 102, e1900131.

13. Heng Zhang, Wei-long Zhong, Bo Sun, Guang Yang, Yan-rong Liu, Bi-jiao Zhou, Xin Chen, Xiang-yan Jing, Long-cong Huai, Ning Liu, Zhi-yuan Zhang, Mi-mi Li, Jing-xia Han, Kai-liang Qiao,Jing Meng, Hong-gang Zhou,* Shuang Chen,* Cheng Yang,* and Tao Sun* iScience, 2019, 21, 549–561.

12. Shuanglin Qin, Tongtong Liu, Yunhao Luo, Jun Yan, Hong Kang, Shende Jiang*,

Guang Yang* Synlett 2019, 30, 593-599.

11. Shuanglin Qin, Tongtong Liu, Yunhao Luo, Shende Jiang and Guang Yang* Org. Chem. Front. 2019, 6, 732-735

10. Shaoyu Liu, Hui Ma, Zhanwen Zhang, Liping Lin, Gongjun Yuan, Xiaolan Tang, Dahong Nie,Shende Jiang, Guang Yang*, Ganghua Tang* Theranostics 2019, 9, 1144-1153.

9. Yuan Qin, Hui-juan Liu, Meng Li, Deng-hui Zhai, Yuan-hao Tang, Lan Yang, Kai-liang Qiao, Jia-huan Yang, Wei-long Zhong, Qiang Zhang, Yan-rong Liu, Guang Yang*, Tao Sun*, Cheng Yang* EBioMed. 2018, 38, 25-36.

8. Xinhua Liu, Benlong Li, Zhen Zhang, Yujiao Wei, Zhongxin Xu, Shuanglin Qin, Ning Liu, Rui Zhao, Junya Peng, Guang Yang, Min Qi, Tongtong Liu, Maodun Xie, Shuangwei Liu, Xian Gao, Cheng Lu, Lijun Zhu, Xinyu Long, Hong Kang, Tao Sun, Honggang Zhou, Mingming Wei,* Guang Yang,* Cheng Yang* J. Med. Chem. 2018, 61, 10814−10833.

7. Xiaohe Li, Cheng Lu, Shuangwei Liu, shuaishuai Liu, Chengcheng Su, Ting Xiao, Zhun Bi, Pengzhen Sheng, Mengying Huang, Xinhua Liu, Yujiao Wei, Lin Zhao, Shengxiang Miao, Jiahe Mao, Kai Huang, Shaoyan Gao, Ning Liu, Min Qi, Tongtong Liu, Shuanglin Qin, Luqing Wei, Tao Sun, Wen Ning, Guang Yang,* Honggang Zhou,* Cheng Yang,* Eur. J. Med. Chem. 2018, 156, 229-247.

6. Shuangwei Liu, Xian Gao, Lisong Zhang, Shuanglin Qin, Mingming Wei, Ning Liu, Rui Zhao, Benlong Li, Ye Meng, Gang Lin, Cheng Lu, Xinhua Liu, Maodun Xie, Tongtong Liu, Honggang Zhou, Min Qi,* Guang Yang,* Cheng Yang,* Eur. J. Med. Chem. 2018, 156, 21-42.

5. Shuanglin Qin, Shuangwei Liu, Yuting Cao, Jiangnan Li, Chuanke Chong, Tongtong Liu, Yunhao Luo, Jiyun Hu, Shende Jiang, Honggang Zhou, Guang Yang* and Cheng Yang* Org. Lett. 2018, 20, 1350−1354.

4. Yuan Qin, Guang Yang, Meng Li, Hui-juan Liu, Wei-long Zhong, Xueqin Yan, Kai-liang Qiao, Jia-huan Yang, Deng-hui Zhai, Wei Yang, Shuang Chen, Hong-gang Zhou, Tao Sun* and Cheng Yang* Oncotarget, 2018, 8, 103815-103827.

3. Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang,* Guang Yang,* and Yue Chen* J. Med. Chem. 2017, 60, 1189-1209.

2. Jiangnan Li, Shende Jiang, George Procopiou, Robert A. Stockman,* and

Guang Yang* Eur. J. Org. Chem. 2016, 3500-3504.

1. Feng Sang, Yahui Ding, Jinghan Wang, Bingxia Sun, Jianlei Sun, Yan Geng, Zhang Zhang, Ke Ding, Ling-Ling Wu, Jian-Wei Liu, Cuigai Bai, Guang Yang,* Quan Zhang,* Lu-Yuan Li,* and Yue Chen* J. Med. Chem. 2016, 59, 1184-1196.

Teaching

[1]Undergraduate: Molecular Genetics of Medicine

[2]Master: Advance in Human Medical Genetics